Hoffman I E A, Lauwerys B R, De Keyser F, Huizinga T W J, Isenberg D, Cebecauer L, Dehoorne J, Joos R, Hendrickx G, Houssiau F, Elewaut D
Centre for Paediatric Rheumatology, Ghent University Hospital, Ghent, Belgium.
Ann Rheum Dis. 2009 Mar;68(3):412-5. doi: 10.1136/ard.2008.094813. Epub 2008 Oct 17.
To investigate differences in clinical signs and symptoms, and in antinuclear antibodies (ANA), between patients with juvenile-onset and adult-onset systemic lupus erythematosus (SLE).
Clinical and serological data of 56 patients with juvenile-onset SLE were compared with data of 194 patients with adult-onset SLE. ANA were determined by line immunoassay and by indirect immunofluorescence on Crithidia luciliae.
Renal involvement, encephalopathy and haemolytic anaemia were seen, and anti-dsDNA, anti-ribosomal P and antihistone antibodies found, significantly more often in juvenile-onset SLE. Anti-dsDNA antibodies were directly associated, and anti-ribosomal P antibodies inversely associated, with renal involvement in juvenile-onset SLE. In juvenile patients with SLE and anti-dsDNA and without anti-ribosomal P antibodies the odds ratio for glomerulonephritis was 9.00; no patients with anti-ribosomal P but without anti-dsDNA had renal involvement.
Patients with juvenile-onset SLE more often have renal involvement and encephalopathy than patients with adult-onset SLE. Anti-ribosomal P, anti-dsDNA and antihistone antibodies are more often found in patients with juvenile-onset SLE.
研究青少年起病型和成人起病型系统性红斑狼疮（SLE）患者在临床症状体征及抗核抗体（ANA）方面的差异。
将56例青少年起病型SLE患者的临床和血清学数据与194例成人起病型SLE患者的数据进行比较。ANA通过线性免疫测定法及在利什曼原虫上的间接免疫荧光法测定。
青少年起病型SLE患者中肾脏受累、脑病及溶血性贫血更为常见，抗双链DNA（dsDNA）、抗核糖体P及抗组蛋白抗体的检出率也更高。在青少年起病型SLE中，抗dsDNA抗体与肾脏受累直接相关，抗核糖体P抗体与肾脏受累呈负相关。在患有SLE且有抗dsDNA但无抗核糖体P抗体的青少年患者中，肾小球肾炎的比值比为9.00；没有抗核糖体P但无抗dsDNA的患者出现肾脏受累。
与成人起病型SLE患者相比，青少年起病型SLE患者肾脏受累和脑病更为常见。抗核糖体P、抗dsDNA及抗组蛋白抗体在青少年起病型SLE患者中更为常见。
