Dzhafarov F I
Biull Eksp Biol Med. 1991 Jun;111(6):629-32.
Possibility of restoration of food intake and other related functions impaired after lesion of lateral hypothalamus was studied on 45 male albino non-strain rats divided into 3 groups with 15 per each. Neuropeptides beta-lipotropin (beta-LPT) and its derivative beta-endorphin were used as compensation factors. The parameters recorded were: volume of food and water intake, diuresis, body weight and temperature, frequencies of rest periods, comforting forms of behavior and orienting-exploratory activity. The results revealed that lesion of lateral hypothalamus resulted in the formation of specific central and peripheral syndrome responsible for the impairment of food intake and other related functions. Intracerebroventricular injections of beta-LPT and beta-endorphin facilitated compensation of impaired functions caused by lesion of lateral hypothalamus. The data were analyzed on the basis of the systems approach to the organism's physiological functions.
对45只雄性白化非品系大鼠进行研究，这些大鼠被分为3组，每组15只，旨在探讨下丘脑外侧损伤后食物摄入及其他相关功能恢复的可能性。使用神经肽β-促脂素（β-LPT）及其衍生物β-内啡肽作为补偿因子。记录的参数包括：食物和水的摄入量、尿量、体重和体温、休息期频率、舒适行为形式以及定向探索活动。结果显示，下丘脑外侧损伤导致形成特定的中枢和外周综合征，从而造成食物摄入及其他相关功能受损。脑室内注射β-LPT和β-内啡肽有助于补偿下丘脑外侧损伤所导致的功能受损。数据基于对机体生理功能的系统方法进行分析。
