Lee Young Ho, Woo Jin-Hyun, Choi Seong Jae, Ji Jong Dae, Song Gwan Gyu
Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, Seoul, South Korea.
Rheumatol Int. 2009 Mar;29(5):539-44. doi: 10.1007/s00296-008-0745-y. Epub 2008 Oct 19.
The association between the A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 gene (LRP5) with bone mineral density (BMD) has been studied, but results have been mixed. Accordingly, the authors performed a meta-analysis on studies on the association between the A1330V LRP5 polymorphism and BMD. Appropriate studies were identified using MEDLINE and by manual searching. A total of 7 separate comparisons were considered in this meta-analysis. Individuals with the AA genotype showed significantly higher lumbar BMD than those with the AV/VV or VV genotype. Weighted mean differences (WMDs) were 0.147 g/cm(2) (95% confidence interval [CI] 0.069-0.224, P < 0.001) and 0.182 g/cm(2) (95% CI 0.024-0.340, P = 0.024) without between-study heterogeneity for AA versus AV/VV and AA versus VV, respectively. Six studies analyzed femur neck (FN) BMD. Individuals with the AA genotype had a significantly higher FN BMD than those with the AV/VV genotype (WMD = 0.165 g/cm(2), 95% CI = 0.087-0.215, P < 0.001), without between-study heterogeneity. Trochanter BMD was measured in three studies. Results showed that subjects with the AA genotype tended to have higher BMD than patients with the AV or VV genotype (WMD = 0.136 g/cm(2), 95% CI = -0.002 to 0.274, P = 0.053). In conclusion, this meta-analysis shows that the LRP5 A1330V polymorphism is associated with BMD, and that individuals with the AA genotype have a higher BMD than those with the AV/VV or VV genotype.
低密度脂蛋白受体相关蛋白5基因（LRP5）的A1330V多态性与骨密度（BMD）之间的关联已得到研究，但结果不一。因此，作者对关于A1330V LRP5多态性与BMD关联的研究进行了荟萃分析。通过MEDLINE检索及手工检索确定了合适的研究。该荟萃分析共纳入7项独立比较。AA基因型个体的腰椎骨密度显著高于AV/VV或VV基因型个体。AA与AV/VV、AA与VV比较时，加权平均差（WMD）分别为0.147g/cm²（95%置信区间[CI]0.069 - 0.224，P < 0.001）和0.182g/cm²（95%CI 0.024 - 0.340，P = 0.024），研究间无异质性。6项研究分析了股骨颈（FN）骨密度。AA基因型个体的FN骨密度显著高于AV/VV基因型个体（WMD = 0.165g/cm²，95%CI = 0.087 - 0.215，P < 0.001），研究间无异质性。三项研究测量了大转子骨密度。结果显示，AA基因型受试者的骨密度往往高于AV或VV基因型患者（WMD = 0.136g/cm²，95%CI = -0.002至0.274，P = 0.053）。总之，该荟萃分析表明LRP5 A1330V多态性与骨密度相关，且AA基因型个体的骨密度高于AV/VV或VV基因型个体。
