Yi Jiayong, Cai Yu, Yao Zhenjun, Lin Jianping
Department of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
PLoS One. 2013 Dec 23;8(12):e85052. doi: 10.1371/journal.pone.0085052. eCollection 2013.
A number of studies have examined the association between the polymorphisms of the low-density lipoprotein receptor-related protein 5 gene (LRP5), but previous results have been inconclusive. Thus we performed a meta-analysis of studies on the association between the LRP5 polymorphisms and bone mineral density (BMD) to assess their pooled effects.
Published literature from PubMed, EMBASE and ISI web of science were searched for eligible publications. Weighted mean difference (WMD) and 95% confidence interval (CI) was calculated using fixed- or random-effects model.
A total of 19 studies with 25773 subjects were considered in this meta-analysis. Of them, 17 examined the association between the A1330V polymorphism and BMD, 8 were focused on the V667M polymorphism, and 2 analyzed the Q89R polymorphism. Individuals with the A1330V AA genotype showed significantly higher BMD than those with the AV/VV genotypes [at lumbar spine (LS): WMD = 0.02 g/cm², 95% CI = 0.01-0.03, P < 10⁻⁴; at femur neck (FN): WMD = 0.01 g/cm², 95% CI = 0.00-0.02, P = 0.01] or VV genotype (at LS: WMD = 0.02 g/cm², 95% CI = 0.01-0.04, P = 0.01). Significant associations were also detected in the analysis for V667M (VV vs. VM/MM: WMD at LS = 0.02 g/cm², 95% CI = 0.02-0.03, P < 10⁻⁵; WMD at FN = 0.01 g/cm², 95% CI = 0.01-0.02, P = 0.0002). As for Q89R, subjects with the QQ genotype tended to have higher BMD than those with the QR/RR genotypes at FN (WMD = 0.03 g/cm², 95% CI = 0.01-0.05, P = 0.005).
This meta-analysis demonstrated that the LRP5 polymorphisms may be modestly associated with BMD of LS and FN.
许多研究探讨了低密度脂蛋白受体相关蛋白5基因（LRP5）多态性之间的关联，但先前的结果尚无定论。因此，我们对LRP5多态性与骨密度（BMD）之间关联的研究进行了荟萃分析，以评估其合并效应。
检索PubMed、EMBASE和ISI科学网的已发表文献，寻找符合条件的出版物。采用固定效应或随机效应模型计算加权平均差（WMD）和95%置信区间（CI）。
本荟萃分析共纳入19项研究，涉及25773名受试者。其中，17项研究探讨了A1330V多态性与BMD的关联，8项聚焦于V667M多态性，2项分析了Q89R多态性。A1330V AA基因型个体的骨密度显著高于AV/VV基因型个体[腰椎（LS）：WMD = 0.02 g/cm²，95% CI = 0.01 - 0.03，P < 10⁻⁴；股骨颈（FN）：WMD = 0.01 g/cm²，95% CI = 0.00 - 0.02，P = 0.01]或VV基因型个体（腰椎：WMD = 0.02 g/cm²，95% CI = 0.01 - 0.04，P = 0.01）。在V667M分析中也检测到显著关联（VV与VM/MM：腰椎WMD = 0.02 g/cm²，95% CI = 0.02 - 0.03，P < 10⁻⁵；股骨颈WMD = 0.01 g/cm²，95% CI = 0.01 - 0.02，P = 0.0002）。至于Q89R，QQ基因型受试者在股骨颈处的骨密度往往高于QR/RR基因型受试者（WMD = 0.03 g/cm²，95% CI = 0.01 - 0.05，P = 0.005）。
本荟萃分析表明，LRP5多态性可能与腰椎和股骨颈的骨密度存在适度关联。
