Shih K L, Raad M K, Hu J C, Gresh W J, Jiries S I, Caldwell L J, Bergamini M V
Sola/Barnes-Hind, Sunnyvale, CA 94086.
CLAO J. 1991 Jul;17(3):165-8.
The antimicrobial activities of three non-peroxide soft contact lens chemical disinfection systems--ReNu Multi-Purpose Solution (0.00005% polyaminopropyl biguanide), Opti-Soft Disinfecting Solution (0.001% polyquaternium-1), and Opti-Free Rinsing, Disinfecting & Storage Solution (0.001% polyquaternium-1)--were compared to Soft Mate Disinfecting Solution (0.005% chlorhexidine digluconate). Each product was separately inoculated with each of five microorganisms at approximately 10(6) microorganisms per mL. All of the solutions demonstrated excellent disinfecting activity against Pseudomonas aeruginosa and Staphylococcus epidermidis, with complete disinfection occurring within 4 hours. Only Soft Mate disinfected Serratia marcescens within 4 hours. ReNu reduced the microorganisms to 10-100 cells/mL and Opti-Soft and Opti-Free reduced the number to 10(2)-10(3) cells/mL. For the fungal species, Soft Mate showed excellent activity against Candida albicans (disinfection in 4 hours) and reduced Aspergillus fumigatus to 10(3) spores/mL in 4 hours. After 4 hours ReNu, Opti-Soft, and Opti-Free had reduced C. albicans only slightly, to 10(5) cells/mL and displayed virtually no disinfecting activity against A. fumigatus. For these newer chemical disinfection systems, diligent cleaning and rinsing of the soft contact lenses are the most important steps in the patient care regimen.
将三种非过氧化物软性隐形眼镜化学消毒系统——视康多功能护理液（0.00005%聚氨基丙基双胍）、Opti-Soft消毒护理液（0.001%聚季铵盐-1）和傲滴恒润护理液（0.001%聚季铵盐-1）——的抗菌活性与Soft Mate消毒护理液（0.005%葡萄糖酸氯己定）进行了比较。每种产品分别接种五种微生物中的每一种，接种浓度约为每毫升10⁶个微生物。所有溶液对铜绿假单胞菌和表皮葡萄球菌均表现出优异的消毒活性，4小时内实现完全消毒。只有Soft Mate在4小时内对粘质沙雷氏菌进行了消毒。视康多功能护理液将微生物数量减少到10 - 100个/毫升，Opti-Soft和傲滴恒润护理液将数量减少到10² - 10³个/毫升。对于真菌种类，Soft Mate对白色念珠菌表现出优异的活性（4小时内消毒），并在4小时内将烟曲霉数量减少到10³个孢子/毫升。4小时后，视康多功能护理液、Opti-Soft和傲滴恒润护理液仅将白色念珠菌数量略微减少到10⁵个/毫升，对烟曲霉几乎没有消毒活性。对于这些新型化学消毒系统，在患者护理方案中，认真清洁和冲洗软性隐形眼镜是最重要的步骤。
