β-酪蛋白吗啡肽（BCM）与人类结肠固有层淋巴细胞增殖
Beta-casomorphin (BCM) and human colonic lamina propria lymphocyte proliferation.
作者信息
Elitsur Y, Luk G D
机构信息
Department of Pediatrics, Wayne State University, Detroit, MI.
出版信息
Clin Exp Immunol. 1991 Sep;85(3):493-7. doi: 10.1111/j.1365-2249.1991.tb05755.x.
Abstract
BCM is a milk-derived peptide with opiate-like properties which is absorbed through the gastrointestinal mucosa. It has been shown to affect gastrointestinal motility, absorption and secretion. Recently, modulation of the immune system by BCM was also reported. In this study we investigated the in vitro effect of BCM on the human mucosal immune response as represented by lamina propria lymphocyte (LPL) proliferation. Results show that BCM significantly inhibited concanavalin A (ConA) stimulated LPL DNA synthesis. BCM also inhibited ornithine decarboxylase activity (ODC) in ConA-stimulated LPL. Although BCM also inhibited 12-O-tetradecanoyl phorbol-13-acetate (TPA) stimulated LPL DNA synthesis, the degree of inhibition was much lower than in ConA-stimulated LPL. The anti-proliferative effect of BCM was reversed by the opiate receptor antagonist, neloxone. Our results suggest that BCM may affect the human mucosal immune system, possibly via the opiate receptor.
摘要
BCM是一种具有阿片样特性的乳源肽，可通过胃肠道黏膜吸收。研究表明，它能影响胃肠蠕动、吸收和分泌。最近，也有报道称BCM可调节免疫系统。在本研究中，我们调查了BCM对以固有层淋巴细胞（LPL）增殖为代表的人黏膜免疫反应的体外作用。结果显示，BCM显著抑制了伴刀豆球蛋白A（ConA）刺激的LPL DNA合成。BCM还抑制了ConA刺激的LPL中的鸟氨酸脱羧酶活性（ODC）。虽然BCM也抑制了12-O-十四酰佛波醇-13-乙酸酯（TPA）刺激的LPL DNA合成，但其抑制程度远低于ConA刺激的LPL。阿片受体拮抗剂纳洛酮可逆转BCM的抗增殖作用。我们的结果表明，BCM可能通过阿片受体影响人黏膜免疫系统。
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