• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Immunostimulating hexapeptide from human casein: amino acid sequence, synthesis and biological properties.

作者信息

Parker F, Migliore-Samour D, Floc'h F, Zerial A, Werner G H, Jollès J, Casaretto M, Zahn H, Jollès P

出版信息

Eur J Biochem. 1984 Dec 17;145(3):677-82. doi: 10.1111/j.1432-1033.1984.tb08609.x.

DOI:10.1111/j.1432-1033.1984.tb08609.x
PMID:6548963
Abstract

A hexapeptide obtained from human casein by enzymatic digestion has been purified, sequenced and synthesized; its structure is: Val-Glu-Pro-Ile-Pro-Tyr. In vitro this hexapeptide stimulates the phagocytosis of opsonized sheep red blood cells by murine peritoneal macrophages. Administered intravenously to adult mice, it enhances the resistance to infection with Klebsiella pneumoniae.

摘要

相似文献

1
Immunostimulating hexapeptide from human casein: amino acid sequence, synthesis and biological properties.
Eur J Biochem. 1984 Dec 17;145(3):677-82. doi: 10.1111/j.1432-1033.1984.tb08609.x.
2
Immunosuppressive activity of some peptides related to cycloamanide A (CyA A) and to the active fragment of a peptide immunomodulator from ovine colostrum.一些与环鹅膏肽A（CyA A）以及来自羊初乳的一种肽免疫调节剂活性片段相关的肽的免疫抑制活性。
Arch Immunol Ther Exp (Warsz). 1993;41(5-6):297-301.
3
Enhancement of phagocytic activity of human monocytic-macrophagic cells by immunostimulating peptides from human casein.源自人酪蛋白的免疫刺激肽增强人单核细胞-巨噬细胞的吞噬活性
Immunol Lett. 1988 May;18(1):27-31. doi: 10.1016/0165-2478(88)90065-x.
4
Specific binding sites on human phagocytic blood cells for Gly-Leu-Phe and Val-Glu-Pro-Ile-Pro-Tyr, immunostimulating peptides from human milk proteins.人吞噬血细胞上针对甘氨酰-亮氨酰-苯丙氨酸和缬氨酰-谷氨酰-脯氨酰-异亮氨酰-脯氨酰-酪氨酸（来自人乳蛋白的免疫刺激肽）的特异性结合位点。
Biochim Biophys Acta. 1992 Dec 28;1160(3):251-61. doi: 10.1016/0167-4838(92)90085-r.
5
[Myelopeptides: isolation and structure].[肌肽：分离与结构]
Bioorg Khim. 1998 Jun;24(6):403-7.
6
Biologically active casein peptides implicated in immunomodulation.与免疫调节有关的具有生物活性的酪蛋白肽。
J Dairy Res. 1989;56(3):357-62. doi: 10.1017/s0022029900028806.
7
Effects of 'casoparan', a peptide isolated from casein hydrolysates with mastoparan-like properties.从酪蛋白水解物中分离出的具有类蜂毒肽特性的肽“酪蛋白蜂毒肽”的作用。
Mediators Inflamm. 2004 Aug;13(4):263-8. doi: 10.1080/09629350400003068.
8
Peptides and their constituent amino acids influence the immune response and phagocytosis in different ways.肽及其组成氨基酸以不同方式影响免疫反应和吞噬作用。
Int J Immunopharmacol. 1992 Oct;14(7):1285-92. doi: 10.1016/0192-0561(92)90065-s.
9
Acetylspiramycin and the immune system. I. Effects of acetylspiramycin on phagocytosis by mouse macrophages in vitro and in vivo.乙酰螺旋霉素与免疫系统。一、乙酰螺旋霉素对小鼠巨噬细胞体内外吞噬作用的影响
Int J Immunopharmacol. 1985;7(6):881-8. doi: 10.1016/0192-0561(85)90051-7.
10
[Endogenous immunoregulatory peptides (myelopeptides): structure, function, and mechanism of action].[内源性免疫调节肽（骨髓肽）：结构、功能及作用机制]
Bioorg Khim. 1999 Nov;25(11):811-5.

引用本文的文献

1
Plant-Derived Proteins and Peptides as Potential Immunomodulators.植物源蛋白质和肽作为潜在的免疫调节剂。
Molecules. 2023 Dec 29;29(1):209. doi: 10.3390/molecules29010209.
2
Extraction, Isolation and Identification of Low Molecular Weight Peptides in Human Milk.人乳中低分子量肽的提取、分离与鉴定
Foods. 2022 Jun 22;11(13):1836. doi: 10.3390/foods11131836.
3
Breastfeeding importance and its therapeutic potential against SARS-CoV-2.母乳喂养的重要性及其对抗 SARS-CoV-2 的治疗潜力。
Physiol Rep. 2021 Feb;9(3):e14744. doi: 10.14814/phy2.14744.
4
Milk Peptides Survive In Vivo Gastrointestinal Digestion and Are Excreted in the Stool of Infants.牛奶肽在体内胃肠道消化中幸存下来，并在婴儿的粪便中排泄。
J Nutr. 2020 Apr 1;150(4):712-721. doi: 10.1093/jn/nxz326.
5
Casein and Peptides Derived from Casein as Antileukaemic Agents.酪蛋白及源自酪蛋白的肽作为抗白血病药物
J Oncol. 2019 Sep 8;2019:8150967. doi: 10.1155/2019/8150967. eCollection 2019.
6
Revisiting the Case of an Intramolecular Hydrogen Bond Network Forming Four- and Five-Membered Rings in d-Glucose.重新审视在d-葡萄糖中形成四元环和五元环的分子内氢键网络的案例。
ACS Omega. 2018 Aug 30;3(8):10250-10254. doi: 10.1021/acsomega.8b01455. eCollection 2018 Aug 31.
7
Immunomodulatory Protein Hydrolysates and Their Application.免疫调节蛋白水解物及其应用。
Nutrients. 2018 Jul 14;10(7):904. doi: 10.3390/nu10070904.
8
Human beta casein fragment (54-59) modulates M. bovis BCG survival and basic transcription factor 3 (BTF3) expression in THP-1 cell line.人β酪蛋白片段（54-59）调节牛结核分枝杆菌生存和 THP-1 细胞系中基本转录因子 3（BTF3）的表达。
PLoS One. 2012;7(9):e45905. doi: 10.1371/journal.pone.0045905. Epub 2012 Sep 28.
9
2008 Landis Award lecture. Inflammation and the autodigestion hypothesis.2008年兰迪斯奖讲座。炎症与自身消化假说。
Microcirculation. 2009 May;16(4):289-306. doi: 10.1080/10739680902801949.
10
Effects of 'casoparan', a peptide isolated from casein hydrolysates with mastoparan-like properties.从酪蛋白水解物中分离出的具有类蜂毒肽特性的肽“酪蛋白蜂毒肽”的作用。
Mediators Inflamm. 2004 Aug;13(4):263-8. doi: 10.1080/09629350400003068.