Faith R E, Liang H J, Murgo A J, Plotnikoff N P
Clin Immunol Immunopathol. 1984 Jun;31(3):412-8. doi: 10.1016/0090-1229(84)90093-x.
To further define the effects of enkephalins on immune function, the effect of methionine-enkephalin and leucine-enkephalin on natural killer cell (NK) activity in isolated human peripheral blood lymphocytes was investigated. Incubation of lymphocytes with either enkephalin resulted in significant increases in natural killer cell activity. At effector:target cell ratios of 11:1 methionine-enkephalin significantly (P less than 0.05) enhanced NK activity at dilutions of 10(-6), 10(-8), 10(-10), and 10(-14) mg/ml, while leucine-enkephalin significantly (P less than 0.05) enhanced NK activity at dilutions of 10(-4), 10(-6), 10(-8), 10(-10), and 10(-14) mg/ml. Cells from individuals with low NK activity showed greater percentage increases in NK activity following enkephalin than did cells from individuals with high NK activity.
为了进一步明确脑啡肽对免疫功能的影响，研究了甲硫氨酸脑啡肽和亮氨酸脑啡肽对分离出的人外周血淋巴细胞中自然杀伤细胞（NK）活性的作用。用任何一种脑啡肽孵育淋巴细胞都会导致自然杀伤细胞活性显著增加。在效应细胞与靶细胞比例为11:1时，甲硫氨酸脑啡肽在10(-6)、10(-8)、10(-10)和10(-14)mg/ml稀释度下显著（P小于0.05）增强NK活性，而亮氨酸脑啡肽在10(-4)、10(-6)、10(-8)、10(-10)和10(-14)mg/ml稀释度下显著（P小于0.05）增强NK活性。与NK活性高的个体的细胞相比，NK活性低的个体的细胞在脑啡肽作用后NK活性的百分比增加更大。
