Chung Su Jin, Kim Joo Sung, Kim Hansoo, Kim Sang Gyun, Kim Chul Woo, Jung Hyun Chae, Song In Sung
Seoul National University Hospital Healthcare System, Yeoksam-dong, Gangnam-gu, Yongon-Dong, Chongno-Gu, Seoul, Republic of Korea.
J Clin Gastroenterol. 2009 Apr;43(4):312-7. doi: 10.1097/MCG.0b013e31816a48f8.
Little is still known regarding the clinical features and prognosis of gastric mucosa-associated lymphoid tissue (MALT) lymphoma without Helicobacter pylori (H. pylori) infection.
From January 1996 to April 2006, a total of 185 patients with gastric MALT lymphoma were enrolled at Seoul National University Hospital. To assess the differences in clinical characteristics and long-term outcomes between H. pylori-negative (n=29, 15.7%) and H. pylori-positive (n=156, 84.3%) cases, we compared these 2 types of lymphoma.
The overall median follow-up period was 39 months. There were no significant differences between the 2 groups in terms of age, macroscopic phenotype, or histologic grade. H. pylori-negative group showed male predominancy (72.4%) and higher percentage of proximal stomach location (62.1%). Although H. pylori-negative lymphomas were more frequently presented as advanced disease (stage IIE or IV, 37.9%), no significant differences in both the overall complete response and overall survival rates were observed between the 2 groups.
Our results suggest that H. pylori-negative gastric MALT lymphoma shows a favorable long-term outcome, which is comparable to that of H. pylori-positive lymphoma.
关于无幽门螺杆菌（H. pylori）感染的胃黏膜相关淋巴组织（MALT）淋巴瘤的临床特征和预后，目前仍知之甚少。
1996年1月至2006年4月，首尔国立大学医院共纳入185例胃MALT淋巴瘤患者。为评估幽门螺杆菌阴性（n = 29，15.7%）和幽门螺杆菌阳性（n = 156，84.3%）病例在临床特征和长期结局方面的差异，我们对这两种类型的淋巴瘤进行了比较。
总体中位随访期为39个月。两组在年龄、大体表型或组织学分级方面无显著差异。幽门螺杆菌阴性组男性占优势（72.4%），胃近端部位的比例更高（62.1%）。尽管幽门螺杆菌阴性淋巴瘤更常表现为晚期疾病（IIE期或IV期，37.9%），但两组在总体完全缓解率和总生存率方面均未观察到显著差异。
我们的结果表明，幽门螺杆菌阴性的胃MALT淋巴瘤显示出良好的长期结局，与幽门螺杆菌阳性淋巴瘤相当。
