Moggia A V, Harris G S, Dunson T R, Diaz R, Moggia M S, Ferrer M A, McMullen S L
Family Health International, Research Triangle Park, NC 27709.
Contraception. 1991 Jul;44(1):31-43. doi: 10.1016/0010-7824(91)90104-n.
A non-randomized comparative clinical trial of the progestin-only oral contraceptive (POC), Ovrette (75 mcg norgestrel) (Wyeth), versus non-hormonal methods was conducted at two clinics in Buenos Aires, Argentina. The trial was designed to assess the breast-feeding patterns of women choosing progestin-only oral contraception and non-hormonal methods of contraception, and to study the relationship between lactation and the clinical performance of a POC. Five-hundred women were allocated to either the progestin-only pill group (n = 250) or to the non-hormonal group (n = 250) and were followed up monthly for six months after admission. Measurements in mean infant weight, mean infant length, and mean head circumference were similar throughout the follow-up period. Non-hormonal users reported significantly more self-perceived decreases in milk production at the 5th and 6th month follow-up intervals. Acceptance and continued use of the pill were excellent, with only one woman discontinuing because of a pregnancy which was attributed to user failure. The principal side effect reported by women in both groups was intermenstrual bleeding.
在阿根廷布宜诺斯艾利斯的两家诊所进行了一项关于仅含孕激素的口服避孕药（POC）奥复婷（75微克炔诺孕酮）（惠氏公司生产）与非激素避孕方法的非随机对照临床试验。该试验旨在评估选择仅含孕激素口服避孕法和非激素避孕法的女性的母乳喂养模式，并研究泌乳与仅含孕激素口服避孕药临床效果之间的关系。500名女性被分为仅含孕激素药丸组（n = 250）或非激素组（n = 250），入院后每月随访6个月。在整个随访期间，婴儿的平均体重、平均身长和平均头围测量值相似。非激素避孕法使用者在第5个月和第6个月随访时报告的自我感觉乳汁分泌减少情况明显更多。药丸的接受度和持续使用率很高，只有一名女性因怀孕停药，这归因于使用者自身失误。两组女性报告的主要副作用都是经间期出血。
