Peralta O, Díaz S, Juez G, Herreros C, Casado M E, Salvatierra A M, Miranda P, Durán E, Croxatto H B
Contraception. 1983 Jan;27(1):27-38. doi: 10.1016/0010-7824(83)90053-7.
The study was designed to test the long-term influence of a low-dose oral contraceptive upon lactation and infant growth when treatment was initiated at day 90 postpartum. The contraceptive tested contained ethinyl estradiol 0.03 mg and levonorgestrel 0.15 mg. The control group was formed by women who chose non-hormonal contraception at the same postpartum time. Only cases who were in exclusive breast-feeding with a minimal infant daily weight increase of 20 g per day during the third month of age were included. The oral contraceptive group showed a significantly lower percentage of cases in full nursing from the 6th postpartum month and a significantly lower infant weight increase during the 4th month of age when compared to the control group. No differences were found in the absolute infant weight up to one year of age. No adverse side effects upon infant's health were detected. It was concluded that the oral contraceptive tested showed a moderate inhibitory influence upon lactation when treatment was initiated at day 90 postpartum.
该研究旨在测试产后90天开始使用低剂量口服避孕药对哺乳及婴儿生长的长期影响。所测试的避孕药含有0.03毫克炔雌醇和0.15毫克左炔诺孕酮。对照组由在相同产后时间选择非激素避孕的女性组成。仅纳入在第三个月龄时进行纯母乳喂养且婴儿每日体重增加最少为20克的病例。与对照组相比，口服避孕药组从产后第6个月起纯母乳喂养的病例百分比显著降低，且在第4个月龄时婴儿体重增加显著更低。在1岁以内婴儿的绝对体重方面未发现差异。未检测到对婴儿健康的不良副作用。得出的结论是，产后90天开始使用所测试的口服避孕药对哺乳有中度抑制作用。
