Aroni Kyriaki, Grapsa Antonia, Lazaris Andreas C, Kavantzas Nikolaos, Kordosis Theodoros, Patsouris Efstratios S
Dermatopathology Section, 1st Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Int J Dermatol. 2008 Sep;47(9):911-7. doi: 10.1111/j.1365-4632.2008.03723.x.
Vitiligo is probably the end result of different interacting processes.
To determine the possible roles of neural and apoptotic mechanisms in the pathogenesis of vitiligo.
Fifty-six biopsies from 28 patients with generalized vitiligo (28 from depigmented lesional areas and 28 from clinically nondepigmented skin at the periphery of the same areas) were examined; the panaxonal marker neuropeptide protein gene product 9.5 (PGP 9.5) and apoptosis were investigated using immunohistochemistry.
Statistically significant differences were detected in the numbers of PGP 9.5-positive nerve fibers/axons in the papillary dermis between the center and periphery of the lesions (i.e. increased at the center in comparison with the periphery). A statistically significant inverse association was found between PGP 9.5 immunostaining in the dermis at the lesion center and the duration of the disease. When apoptosis and PGP 9.5 expression were compared, there was an identical distribution of PGP 9.5-positive nerve fibers/axons and apoptotic cells in the epidermis (i.e. basal in the lesion center; diffuse at the lesion periphery).
There is a possible connection between the neural and apoptotic pathogenetic theories of vitiligo.
白癜风可能是不同相互作用过程的最终结果。
确定神经和凋亡机制在白癜风发病机制中的可能作用。
对28例泛发性白癜风患者的56份活检标本（28份取自色素脱失的皮损区，28份取自同一区域周边临床上无色素脱失的皮肤）进行检查；采用免疫组织化学方法研究全轴突标记物神经肽蛋白基因产物9.5（PGP 9.5）和细胞凋亡情况。
在皮损中心和周边的乳头真皮层中，PGP 9.5阳性神经纤维/轴突数量存在统计学显著差异（即中心部位相较于周边有所增加）。在皮损中心真皮层的PGP 9.5免疫染色与疾病持续时间之间发现了统计学显著的负相关。当比较细胞凋亡和PGP 9.5表达时，表皮中PGP 9.5阳性神经纤维/轴突和凋亡细胞的分布相同（即皮损中心位于基底；皮损周边呈弥漫性）。
白癜风的神经和凋亡发病理论之间可能存在联系。
