Department of Dermatopathology, National and Kapodistrian University of Athens, Greece.
Arch Dermatol Res. 2010 Oct;302(8):601-7. doi: 10.1007/s00403-010-1040-9. Epub 2010 Mar 5.
The larger number of T-lymphocytes in the periphery of vitiligo lesions and their association with angiogenesis are reported. The objective of this study was to investigate angiogenesis, VEGF and mast cell in vitiligo lesions. Specimens of 30 patients' biopsies, from lesional and perilesional nondepigmented skin were stained for mast cells, CD34 and VEGF. The evaluation was made by image analysis and the measured variables were statistically analyzed. A significantly increased number of CD34 and VEGF positive vessels and mast cells were detected in the centre of the lesion than in the periphery (p < 0.0001, p < 0.0001 and p = 0.001). There was a positive correlation of CD34, VEGF and mast cell number between the centre and the periphery of the lesions (r = 0.877, p < 0.0001; r = 0.946, p < 0.0001 and r = 0.863, p < 0.0001, respectively). The increased angiogenesis and mast cell numbers in the area where lymphocyte number is lower may be explained with the stepwise inflammatory process in vitiligo.
据报道，白癜风病变部位的 T 淋巴细胞数量较多，并与血管生成有关。本研究旨在探讨白癜风皮损中的血管生成、VEGF 和肥大细胞。对 30 例患者活检标本的病变和非色素减退性皮损进行肥大细胞、CD34 和 VEGF 染色。通过图像分析进行评估，并对测量变量进行统计学分析。与病变边缘相比，病变中心的 CD34 和 VEGF 阳性血管和肥大细胞数量显著增加（p<0.0001，p<0.0001 和 p=0.001）。病变中心和边缘之间的 CD34、VEGF 和肥大细胞数量呈正相关（r=0.877，p<0.0001；r=0.946，p<0.0001 和 r=0.863，p<0.0001）。在淋巴细胞数量较低的区域，血管生成和肥大细胞数量的增加可以用白癜风的逐步炎症过程来解释。
