Kutay Ulrike, Hetzer Martin W
Institute of Biochemistry, ETH Zurich, HPM F11.1, Schafmattstr.18, 8093 Zurich, Switzerland.
Curr Opin Cell Biol. 2008 Dec;20(6):669-77. doi: 10.1016/j.ceb.2008.09.010. Epub 2008 Nov 2.
The nuclear envelope (NE) provides a selective barrier between the nuclear interior and the cytoplasm and constitutes a central component of intracellular architecture. During mitosis in metazoa, the NE breaks down leading to the complete mixing of the nuclear content with the cytosol. Interestingly, many NE components actively participate in mitotic progression. After chromosome segregation, the NE is reassembled around decondensing chromatin and the nuclear compartment is reestablished in the daughter cells. Here, we summarize recent progress in deciphering the molecular mechanisms underlying NE dynamics during cell division.
核膜（NE）在细胞核内部与细胞质之间提供了一个选择性屏障，并且是细胞内结构的核心组成部分。在后生动物的有丝分裂过程中，核膜解体，导致细胞核内容物与细胞质完全混合。有趣的是，许多核膜成分积极参与有丝分裂进程。染色体分离后，核膜围绕解聚的染色质重新组装，并且在子细胞中重新建立细胞核区室。在此，我们总结了在解析细胞分裂过程中核膜动态变化潜在分子机制方面的最新进展。
