Löwenberg A, Orie N G
Scand J Respir Dis. 1976;57(6):290-300.
A consecutive series of 282 nurses of the University Hospital, Groningen, with complaints of the nose and/or throat associated with coughing and/or hoarseness were examined between April 1965 and February 1968. The intent was to obtain information on the incidence of viral, mycoplasma and bacterial infections, and on the relationship of these infections in nurses with chronic nonspecific lung disease (CNSLD). The following results were obtained: 1. Virus infections caused by influenza virus (A, B, and C), rhinovirus, parainfluenza virus, adenovirus, respiratory syncytial virus and/or Mycoplasma pneumoniae were confirmed in 30% of the nurses examined; if influenza was excluded, this figure was 20%. 2. Rhinovirus infections were found more often than all the other virus infections together (if influenza was excluded). 3. Approximately 25% of the nurses had signs of CNSLD. 4. In the course of the virus infections, nine out of 14 nurses with a history of chronic obstructive lung disease showed symptoms of exacerbation or recurrence of a generalized bronchial obstruction. 5. There was no difference in the incidence of virus infections in the group of nurses with and without CNSLD. 6. There were more bacterial infections (without a confirmed virus infection) in the subjects with CNSLD than in those without CNSLD. 7. There were more combined viral/bacterial infections in the patients with CNSLD than in those without CNSLD. 8. Patients with influenza did not have more bacterial infections than patients with other virus infections. This is also true for patients with CNSLD and influenza when regarded separately. The patients without CNSLD tended to have more bacterial infections with influenza than with other viral infections, but the difference was not statistically significant.
1965年4月至1968年2月期间，对格罗宁根大学医院连续282名主诉有鼻和/或喉相关症状并伴有咳嗽和/或声音嘶哑的护士进行了检查。目的是获取有关病毒、支原体和细菌感染的发病率，以及这些感染在患有慢性非特异性肺病（CNSLD）的护士中的关系的信息。获得了以下结果：1. 在接受检查的护士中，30%确诊为由甲型、乙型和丙型流感病毒、鼻病毒、副流感病毒、腺病毒、呼吸道合胞病毒和/或肺炎支原体引起的病毒感染；如果排除流感，这一数字为20%。2. 发现鼻病毒感染比所有其他病毒感染加起来更常见（如果排除流感）。3. 约25%的护士有CNSLD的体征。4. 在病毒感染过程中，14名有慢性阻塞性肺病病史的护士中有9名出现了广泛性支气管阻塞加重或复发的症状。5. 有CNSLD和无CNSLD的护士组中病毒感染的发病率没有差异。6. 有CNSLD的受试者中细菌感染（无确诊病毒感染）比无CNSLD的受试者更多。7. 有CNSLD的患者中病毒/细菌合并感染比无CNSLD的患者更多。8. 流感患者的细菌感染并不比其他病毒感染患者多。单独来看，患有CNSLD和流感的患者也是如此。没有CNSLD的患者流感引起的细菌感染往往比其他病毒感染更多，但差异无统计学意义。
