Day J Michael, Spackman Erica, Pantin-Jackwood Mary J
Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, 934 College Station Road, Athens, Georgia 30605, USA.
Avian Dis. 2008 Sep;52(3):387-91. doi: 10.1637/8190-120607-Reg.
Recently, pathogenesis studies, using genetically distinct turkey-origin reoviruses (TRVs), revealed that poults infected with certain TRV isolates had moderate to severe bursal atrophy, suggesting virus-induced immune dysfunction. In order to characterize the effect of TRV infection on the turkey immune system, classical assays were undertaken to quantify the humoral and cell-mediated immune responses in small Beltsville and broad-breasted white poults infected with the TRV isolate NC/SEP-R44/03. A marked effect on the cutaneous basophil hypersensitivity response, and on the antibody response to Newcastle disease virus (NDV) exposure, was noted in commercial and specific pathogen free (SPF) poults inoculated with NC/SEP-R44/03 at three days of age. Moderate to severe bursal atrophy, similar to that noted previously in SPF poults, occurred in commercial poults inoculated at three days of age. This immune dysfunction and bursal atrophy was not present in commercial poults inoculated at three weeks of age.
最近，利用基因不同的火鸡源呼肠孤病毒（TRV）进行的发病机制研究表明，感染某些TRV分离株的雏火鸡出现中度至重度法氏囊萎缩，提示病毒诱导的免疫功能障碍。为了表征TRV感染对火鸡免疫系统的影响，采用经典试验对感染TRV分离株NC/SEP-R44/03的小贝茨维尔火鸡和宽胸白羽雏火鸡的体液免疫和细胞介导免疫反应进行定量。在3日龄接种NC/SEP-R44/03的商品雏火鸡和无特定病原体（SPF）雏火鸡中，观察到对皮肤嗜碱性粒细胞超敏反应以及对新城疫病毒（NDV）暴露的抗体反应有显著影响。在3日龄接种的商品雏火鸡中出现了中度至重度法氏囊萎缩，与之前在SPF雏火鸡中观察到的情况相似。在3周龄接种的商品雏火鸡中未出现这种免疫功能障碍和法氏囊萎缩。
