Perelman B, Heller E D
Avian Dis. 1983 Jan-Mar;27(1):66-76.
In 1979 it was reported that an infectious bursal disease virus (IBDV) isolated from a case of respiratory disease of turkeys differed antigenically from the chicken isolates of this virus. We injected turkey poults with the turkey-originating TY89 and chicken-originating BD/6 isolates of IBDV and studied their effects on antibody production to the virus, serum immunoglobulin G (IgG), antibody response to sheep erythrocytes, in vitro response of peripheral blood lymphocytes to mitogens, and microscopic structure of the bursa of Fabricius. The chicken isolate BD/6 caused a significant decrease in the response to sheep erythrocytes, lower serum IgG, transient decrease in the response of lymphocytes to PHA, and mild microscopic lesions in the bursa of Fabricius. The turkey isolate TY89, however, caused no obvious damage to the immune system of the infected poults. We suggest that a partial and transient functional disorder of the immune system of poults can occur after infection with IBDV originating from chickens, even if the poults exhibited no clinical signs.
1979年有报道称，从一例火鸡呼吸道疾病中分离出的传染性法氏囊病病毒（IBDV）在抗原性上与该病毒的鸡源分离株不同。我们给小火鸡注射了源自火鸡的IBDV分离株TY89和源自鸡的IBDV分离株BD/6，并研究了它们对该病毒抗体产生、血清免疫球蛋白G（IgG）、对绵羊红细胞的抗体反应、外周血淋巴细胞对有丝分裂原的体外反应以及法氏囊微观结构的影响。鸡源分离株BD/6导致对绵羊红细胞的反应显著降低、血清IgG水平降低、淋巴细胞对PHA的反应短暂下降以及法氏囊出现轻微的微观病变。然而，火鸡源分离株TY89对受感染小火鸡的免疫系统未造成明显损害。我们认为，即使小火鸡没有表现出临床症状，感染源自鸡的IBDV后，小火鸡的免疫系统也可能会出现部分和短暂的功能紊乱。
