Jang Eun-Mi, Choi Myung-Sook, Jung Un Ju, Kim Myung-Joo, Kim Hye-Jin, Jeon Seon-Min, Shin Su-Kyung, Seong Chi-Nam, Lee Mi-Kyung
Department of Nutrition Education, Graduate School of Education, Sunchon National University, Jeonnam 540-742, South Korea.
Metabolism. 2008 Nov;57(11):1576-83. doi: 10.1016/j.metabol.2008.06.014.
This study investigated the effect of curcumin (0.05-g/100-g diet) supplementation on a high-fat diet (10% coconut oil, 0.2% cholesterol, wt/wt) fed to hamsters, one of the rodent species that are most closely related to humans in lipid metabolism. Curcumin significantly lowered the levels of free fatty acid, total cholesterol, triglyceride, and leptin and the homeostasis model assessment of insulin resistance index, whereas it elevated the levels of high-density lipoprotein cholesterol and apolipoprotein (apo) A-I and paraoxonase activity in plasma, compared with the control group. The levels of hepatic cholesterol and triglyceride were also lower in the curcumin group than in the control group. In the liver, fatty acid beta-oxidation activity was significantly higher in the curcumin group than in the control group, whereas fatty acid synthase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and acyl coenzyme A:cholesterol acyltransferase activities were significantly lower. Curcumin significantly lowered the lipid peroxide levels in the erythrocyte and liver compared with the control group. These results indicate that curcumin exhibits an obvious hypolipidemic effect by increasing plasma paraoxonase activity, ratios of high-density lipoprotein cholesterol to total cholesterol and of apo A-I to apo B, and hepatic fatty acid oxidation activity with simultaneous inhibition of hepatic fatty acid and cholesterol biosynthesis in high-fat-fed hamsters.
本研究调查了姜黄素（0.05克/100克饮食）添加到高脂饮食（10%椰子油，0.2%胆固醇，重量/重量）中对仓鼠的影响，仓鼠是在脂质代谢方面与人类关系最密切的啮齿动物物种之一。与对照组相比，姜黄素显著降低了游离脂肪酸、总胆固醇、甘油三酯和瘦素水平以及胰岛素抵抗指数的稳态模型评估值，而提高了血浆中高密度脂蛋白胆固醇、载脂蛋白（apo）A-I水平和对氧磷酶活性。姜黄素组肝脏胆固醇和甘油三酯水平也低于对照组。在肝脏中，姜黄素组脂肪酸β-氧化活性显著高于对照组，而脂肪酸合酶、3-羟基-3-甲基戊二酰辅酶A还原酶和酰基辅酶A：胆固醇酰基转移酶活性显著降低。与对照组相比，姜黄素显著降低了红细胞和肝脏中的脂质过氧化物水平。这些结果表明，姜黄素通过提高血浆对氧磷酶活性、高密度脂蛋白胆固醇与总胆固醇的比率以及apo A-I与apo B的比率，以及肝脏脂肪酸氧化活性，同时抑制高脂喂养仓鼠肝脏中脂肪酸和胆固醇的生物合成，表现出明显的降血脂作用。
