Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran.
Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Curr Med Chem. 2024;31(42):6957-6970. doi: 10.2174/0929867331666230707094644.
Dyslipidemia and altered lipid metabolism are closely involved in the pathogenesis and clinical manifestation of many metabolic and non-metabolic diseases. Therefore, mitigation of pharmacological and nutritional factors together with lifestyle modifications is paramount. One potential nutraceutical exhibiting cell signaling and lipid-modulating properties implicated in dyslipidemias is curcumin. Specifically, recent evidence suggest that curcumin may improve lipid metabolism and prevent dyslipidemia-induced cardiovascular complications several pathways. Although the exact molecular mechanisms involved are not well understood, the evidence presented in this review suggests that curcumin can provide significant lipid benefits via modulation of adipogenesis and lipolysis, and prevention or reduction of lipid peroxidation and lipotoxicity different molecular pathways. Curcumin can also improve the lipid profile and reduce dyslipidemia- dependent cardiovascular problems by impacting important mechanisms of fatty acid oxidation, lipid absorption, and cholesterol metabolism. Although only limited direct supporting evidence is available, in this review we assess the available knowledge regarding the possible nutraceutical effects of curcumin on lipid homeostasis and its possible impacts on dyslipidemic cardiovascular events from a mechanistic viewpoint.
血脂异常和脂质代谢紊乱与许多代谢和非代谢性疾病的发病机制和临床表现密切相关。因此，减轻药物和营养因素以及生活方式的改变至关重要。一种具有细胞信号转导和脂质调节特性的潜在的营养保健品姜黄素与血脂异常有关。具体而言，最近的证据表明，姜黄素可能通过几种途径改善脂质代谢并预防血脂异常引起的心血管并发症。尽管涉及的确切分子机制尚不清楚，但本综述中提出的证据表明，姜黄素可以通过调节脂肪生成和脂肪分解，预防或减少脂质过氧化和脂毒性，从而提供显著的脂质益处不同的分子途径。姜黄素还可以通过影响脂肪酸氧化、脂质吸收和胆固醇代谢的重要机制来改善血脂谱并减少血脂异常相关的心血管问题。尽管只有有限的直接支持证据可用，但在本综述中，我们从机制的角度评估了关于姜黄素对脂质稳态的可能营养保健品作用及其对血脂异常性心血管事件的可能影响的现有知识。
