Li Yi, Li Long-Jiang, Huang Ju, Han Bo, Pan Jian
Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China.
J Oral Maxillofac Surg. 2008 Nov;66(11):2247-53. doi: 10.1016/j.joms.2008.01.041.
As a review of central malignant salivary gland tumor cases in Southwest China in the past 20 years, this study provided the clinical, radiologic, and pathologic information of these rare lesions.
In our study, 22 cases of central malignant salivary gland tumor treated between 1986 to 2006 at West China Stomatology Hospital of Sichuan University were retrospectively analyzed. A thorough review of clinical records was carried out and the histologic diagnosis was revised using the 2005 WHO criteria.
The average age of patients was 46.5 years old, and the peak incidence age of the tumors was in the fourth, fifth, and sixth decades. The male:female ratio was 0.47:1. The clinical manifestation included swelling of the jaw, pain, paraesthesia, tooth mobility, and pain. All the lesions were radiolucent regions with an ill-defined margin. The most frequent histologic type was the mucoepidermoid carcinoma. Local extensive resection of the primary focus was the primary treatment.
Central malignant salivary gland tumors often occurred in the middle-aged patients, and there were more cases in the mandible than in the maxilla. The diagnosis should be based on the case history, clinical, pathologic, and radiologic examinations. The major treatment was extensive resection of primary focus.
作为对中国西南地区过去20年中央型恶性涎腺肿瘤病例的回顾，本研究提供了这些罕见病变的临床、放射学和病理学信息。
在我们的研究中，对1986年至2006年期间在四川大学华西口腔医院接受治疗的22例中央型恶性涎腺肿瘤病例进行了回顾性分析。对临床记录进行了全面审查，并根据2005年世界卫生组织标准对组织学诊断进行了修订。
患者的平均年龄为46.5岁，肿瘤的发病高峰年龄在第四、第五和第六个十年。男女比例为0.47:1。临床表现包括颌部肿胀、疼痛、感觉异常、牙齿松动和疼痛。所有病变均为边界不清的透射区。最常见的组织学类型是黏液表皮样癌。原发灶局部广泛切除是主要治疗方法。
中央型恶性涎腺肿瘤常发生于中年患者，下颌骨的病例比上颌骨多。诊断应基于病史、临床、病理和放射学检查。主要治疗方法是原发灶广泛切除。
