Indu Sudip, Roy Indranil Deb
Division of Oral Pathology, Army Dental Centre (R&R), New Delhi, India.
Commandant, Armed Forces Dental Clinic, New Delhi, India.
J Oral Maxillofac Pathol. 2020 Feb;24(Suppl 1):S37-S41. doi: 10.4103/jomfp.JOMFP_19_20. Epub 2020 Feb 28.
Central adenoid cystic carcinoma (ACC) of the mandible is a rare entity arising from minor salivary glands. Their clinical and radiographic features may be similar to any odontogenic/nonodontogenic pathology, thus making their precise diagnosis wearisome. ACC is well documented for its protracted clinical course, perineural invasion, multiple recurrence rates and its propensity for distant metastases. The aim of this study is to report a rare case of primary central ACC of the mandible with an unusual presentation in terms of location, however, demonstrating the classical features of ACC in histopathology and positivity in immunohistochemistry to S100, calponin and CD117. A thorough clinical, radiographic, CT evaluation and meticulous metastatic workup along with long-term follow-up is advised in such cases. Although central ACC is extremely rare, especially in the anterior mandible, it should be included in the differentials for lesions of the mandible.
下颌骨中央腺样囊性癌（ACC）是一种罕见的起源于小唾液腺的疾病。其临床和影像学特征可能与任何牙源性/非牙源性病变相似，因此精确诊断颇具难度。ACC因其病程迁延、神经侵犯、多次复发率以及远处转移倾向而有充分的文献记载。本研究旨在报告一例罕见的下颌骨原发性中央ACC病例，其在位置方面表现异常，但在组织病理学上显示出ACC的典型特征，免疫组化对S100、钙调蛋白和CD117呈阳性。对于此类病例，建议进行全面的临床、影像学、CT评估以及细致的转移灶检查，并进行长期随访。尽管中央ACC极为罕见，尤其是在下颌骨前部，但在诊断下颌骨病变时应将其纳入鉴别诊断范围。
