Lennell Anne, Kühlmann-Berenzon Sharon, Geli Patricia, Hedin Katarina, Petersson Christer, Cars Otto, Mannerquist Kerstin, Burman Lars G, Fredlund Hans
Department of Clinical Microbiology, Unit for Infectious Disease Control, Orebro University Hospital, Orebro University, Orebro, Sweden.
Acta Paediatr. 2008 Dec;97(12):1672-80. doi: 10.1111/j.1651-2227.2008.01057.x. Epub 2008 Oct 1.
To determine if the use of alcohol-based hand-disinfection as a complement to regular hand washing at daycare centers (DCCs) can reduce the childhood rate of absenteeism.
Children aged 0-6 years attending DCC were studied in a cluster randomized controlled trial during 30 weeks. Thirty matched pairs of DCCs were included in the study, where one of the DCCs was randomized to intervention and the other to control within each pair. The intervention consisted in children and staff using alcohol-based oily disinfectant gel containing 70% ethanol after regular hand washing. The main outcome was the rate of episodes of absence from DCC due to infection. A regression model was fitted at the individual level and controlling several possible confounders for illness. Absences were reported by the parents.
Differences in missing absence reports between the two groups led to only evaluating those 29 DCCs (1431 children) that were able to provide complete reports. In the multivariate regression, the intervention significantly reduced the rate of absenteeism of a child by 12% compared to a child in a control DCC (IRR 95% CI: 0.799-0.965).
Hand-disinfection used by children and staff significantly decreased childrens absences due to infections in Swedish DCCs.
确定在日托中心(DCC)使用酒精类手部消毒作为常规洗手的补充措施是否能降低儿童缺勤率。
在30周内,对参加DCC的0至6岁儿童进行整群随机对照试验。该研究纳入了30对匹配的DCC,每对中的一个DCC被随机分配到干预组,另一个被分配到对照组。干预措施包括儿童和工作人员在常规洗手后使用含70%乙醇的酒精类油性消毒凝胶。主要结局是因感染导致的DCC缺勤率。在个体层面拟合回归模型,并控制几种可能的疾病混杂因素。缺勤情况由家长报告。
两组间缺勤报告缺失情况的差异导致仅对能够提供完整报告的29个DCC(1431名儿童)进行评估。在多变量回归中,与对照DCC中的儿童相比,干预措施使儿童缺勤率显著降低了12%(风险比95%置信区间:0.799 - 0.965)。
在瑞典的DCC中,儿童和工作人员使用手部消毒显著减少了因感染导致的儿童缺勤情况。