Malykhin Nikolai, Concha Luis, Seres Peter, Beaulieu Christian, Coupland Nicholas J
Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada.
Psychiatry Res. 2008 Nov 30;164(2):132-42. doi: 10.1016/j.pscychresns.2007.11.007. Epub 2008 Oct 21.
Diffusion tensor imaging (DTI) provides the opportunity to study white matter tracts in vivo. The goal was to estimate the reliability of DTI tractography for the analysis of limbic and paralimbic white matter. Normative data from 24 healthy subjects and reliability data from four healthy and four depressed subjects were acquired at 1.5 Tesla, using twice-refocused spin-echo, echoplanar DTI and Fluid-Attenuated Inversion Recovery (FLAIR) DTI sequences. Fiber tracking was performed using the Fiber Assignment by Continuous Tracking algorithm. Fractional Anisotropy (FA), trace Apparent Diffusion Coefficient and tract volumes were calculated. The inter-rater (and intra-rater) intraclass correlation coefficients for FA values were as follows: rostral cingulum 0.89 (0.87), dorsal cingulum 0.85 (0.90), parahippocampal cingulum 0.85 (0.95), uncinate fasciculus 0.85 (0.87), medial prefrontal white matter 0.97 (0.99), ventromedial prefrontal white matter 0.92 (0.93), crus of fornix 0.80 (0.81). The reported DTI protocol provides a reliable method to analyze limbic and paralimbic white matter tracts relevant to psychiatric disorders.
扩散张量成像（DTI）为在体研究白质纤维束提供了机会。本研究旨在评估DTI纤维束成像在分析边缘系统和边缘旁白质方面的可靠性。对24名健康受试者获取了标准数据，并对4名健康受试者和4名抑郁症患者获取了可靠性数据，在1.5特斯拉磁场下，使用两次重聚焦自旋回波、回波平面DTI和液体衰减反转恢复（FLAIR）DTI序列。使用连续追踪纤维分配算法进行纤维追踪。计算了分数各向异性（FA）、表观扩散系数迹值和纤维束体积。FA值的评分者间（和评分者内）组内相关系数如下：喙侧扣带束0.89（0.87），背侧扣带束0.85（0.90），海马旁扣带束0.85（0.95），钩束0.85（0.87），内侧前额叶白质0.97（0.99），腹内侧前额叶白质0.92（0.93），穹窿脚0.80（0.81）。所报告的DTI方案为分析与精神疾病相关的边缘系统和边缘旁白质纤维束提供了一种可靠的方法。
