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Treatment outcomes for HIV-uninfected patients with multidrug-resistant and extensively drug-resistant tuberculosis.未感染艾滋病毒的耐多药和广泛耐药结核病患者的治疗结果。
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Utility of mycobacterial interspersed repetitive unit typing for differentiating Mycobacterium tuberculosis isolates in Wuhan, China.分枝杆菌散布重复单位分型在中国武汉鉴别结核分枝杆菌分离株中的应用
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Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa.广泛耐药结核病是南非农村地区结核病与艾滋病毒合并感染患者的死因之一。
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Case definition for extensively drug-resistant tuberculosis.广泛耐药结核病的病例定义。
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Infectious disease. Extensively drug-resistant TB gets foothold in South Africa.传染病。广泛耐药结核病在南非站稳脚跟。
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Discrimination of Mycobacterium tuberculosis complex bacteria using novel VNTR-PCR targets.利用新型VNTR-PCR靶点鉴别结核分枝杆菌复合群细菌
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Genetic diversity in the Mycobacterium tuberculosis complex based on variable numbers of tandem DNA repeats.基于串联DNA重复序列数量可变的结核分枝杆菌复合群中的遗传多样性。
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中国广泛耐药结核分枝杆菌临床分离株的特征分析

Characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates in China.

作者信息

Sun Zhaogang, Chao Yanjie, Zhang Xuxia, Zhang Jianyuan, Li Yan, Qiu Yunqing, Liu Yi, Nie Lihui, Guo Aizhen, Li Chuanyou

机构信息

Department of Bacteriology and Immunology, Beijing Tuberculosis & Thoracic Tumor Research Institute, Tongzhou District, Beijing, China.

出版信息

J Clin Microbiol. 2008 Dec;46(12):4075-7. doi: 10.1128/JCM.00822-08. Epub 2008 Oct 22.

DOI:10.1128/JCM.00822-08
PMID:18945837
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2593274/
Abstract

Thirteen extensively drug-resistant tuberculosis isolates which were highly resistant to a broad spectrum of antituberculosis drugs were identified from 1,926 clinical isolates in China. They had highly diverse mycobacterial interspersed repetitive-unit-variable-number tandem-repeat patterns. Most, but not all, of the drug target genes had mutations contributing to resistance to the corresponding drug.

摘要

在中国的1926份临床分离株中，鉴定出13株对多种抗结核药物具有高度耐药性的广泛耐药结核分枝杆菌分离株。它们具有高度多样的分枝杆菌插入重复单元可变数目串联重复序列模式。大多数（但并非全部）药物靶基因发生了导致对相应药物耐药的突变。