Kulinskiĭ V I, Kolesnichenko L S
Ukr Biokhim Zh. 1976;48(6):683-9.
A possibility is shown to study the catecholamine (CA) action mechanism on the simple and available object, the liver supernatant fraction. Under these conditions the physiological concentrations of CA increase the disulphide reductase (DSR) activity. The effect of adrenaline, noradrenaline and isadrine (isopropylnoradrenaline) is realized through beta-receptors, the mesaton (phenylephrine) effect is realized through receptors differing from the classic ones. Serotonin stimulates DSR too but in an order higher concentration; this effect is blocked by beta-adrenolytic. For CA action the membrane factor is necessary, as the effect takes place only at protracted homogenization or preliminary solubilization by detergents. The additional data are obtained in favour of the hypothesis on the DSR activation through the chain: adenylate cyclase-3',5'-AMP-protein kinase.
有一种可能是利用简单且可得的对象——肝脏上清液部分来研究儿茶酚胺（CA）的作用机制。在这些条件下，CA的生理浓度会增加二硫还原酶（DSR）的活性。肾上腺素、去甲肾上腺素和异丙肾上腺素（异丙基去甲肾上腺素）的作用是通过β受体实现的，新福林（去氧肾上腺素）的作用是通过不同于经典受体的受体实现的。血清素也能刺激DSR，但所需浓度更高；这种作用会被β-肾上腺素能阻断剂所阻断。对于CA的作用，膜因子是必需的，因为这种作用仅在长时间匀浆或用去污剂进行初步溶解时才会发生。还获得了更多数据，支持通过以下途径激活DSR的假说：腺苷酸环化酶-3',5'-AMP-蛋白激酶。
