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寡核苷酸阵列数据库(OligoArrayDb):泛基因组寡核苷酸微阵列探针集数据库。

OligoArrayDb: pangenomic oligonucleotide microarray probe sets database.

作者信息

Rouillard Jean-Marie, Gulari Erdogan

机构信息

Chemical Engineering Department, University of Michigan, 2300 Hayward Street, Ann Arbor, MI 48109, USA.

出版信息

Nucleic Acids Res. 2009 Jan;37(Database issue):D938-41. doi: 10.1093/nar/gkn761. Epub 2008 Oct 23.

Abstract

OligoArrayDb is a comprehensive database containing pangenomic oligonucleotide microarray probe sets designed for most of the sequenced genomes that are not covered by commercial catalog arrays. The availability of probe sequences, associated with custom microarray fabrication services offered by many companies and cores presents the unequalled possibility to perform microarray experiments on most of the sequenced organisms. OligoArrayDb contains more than 2.8 probes per gene in average for more than 600 organisms, mostly archaea and bacteria strains available from public database. On average, 98% of the annotated genes have at least one probe which is predicted to be specific to its intended target in >94% of the cases. OligoArrayDb is weekly updated as new sequenced genomes become available. Probe sequences, in addition to a comprehensive set of annotations can be downloaded from this database. OligoArrayDb is publicly accessible online at http://berry.engin.umich.edu/oligoarraydb.

摘要

OligoArrayDb是一个综合数据库,包含为大多数未被商业目录阵列覆盖的已测序基因组设计的泛基因组寡核苷酸微阵列探针集。许多公司和核心机构提供与定制微阵列制造服务相关的探针序列,这为在大多数已测序生物体上进行微阵列实验提供了无与伦比的可能性。OligoArrayDb平均每个基因包含超过2.8个探针,涵盖600多种生物体,其中大部分是可从公共数据库获得的古细菌和细菌菌株。平均而言,98%的注释基因至少有一个探针,预计在94%以上的情况下对其预期靶标具有特异性。随着新的已测序基因组的出现,OligoArrayDb每周更新一次。除了一套全面的注释外,探针序列也可以从该数据库下载。OligoArrayDb可通过http://berry.engin.umich.edu/oligoarraydb在线公开访问。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbe6/2686523/750dff37d441/gkn761f1.jpg

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