Department of Psychiatry, University of Chicago, Chicago, IL 60637, USA.
J Pediatr Psychol. 2009 Aug;34(7):727-37. doi: 10.1093/jpepsy/jsn111. Epub 2008 Oct 23.
To test whether an association between pain response and depression in females is present during preadolescence using a controlled pain stimulus and a clinically relevant assessment of depressive symptoms.
In a sample of 232 girls, pain threshold and tolerance were assessed at age 10 years using the cold pressor task, and a diagnostic interview was used to assess depression symptoms at 10 and 11 years of age.
Response to pain at age 10 was associated with depressive symptoms at ages 10 and 11; race and pubertal stage moderated the association. Pain response and depression were more strongly associated among girls who had reached advanced stages of pubertal development and among European American girls.
The results add to the existing literature on the co-occurrence of depression and pain by demonstrating modest but consistent concurrent and prospective associations between response to pain and depression among girls during preadolescence.
使用控制的疼痛刺激和临床相关的抑郁症状评估方法，在青春期前阶段检测女性的疼痛反应与抑郁之间是否存在关联。
在 232 名女孩的样本中，使用冷水压力任务在 10 岁时评估疼痛阈值和耐受度，并在 10 岁和 11 岁时使用诊断性访谈评估抑郁症状。
10 岁时的疼痛反应与 10 岁和 11 岁时的抑郁症状相关；种族和青春期阶段调节了这种关联。在已经进入青春期后期发展阶段的女孩和欧裔美国女孩中，疼痛反应和抑郁之间的关联更为密切。
这些结果通过在青春期前阶段的女孩中证明疼痛反应与抑郁之间存在适度但一致的并发和前瞻性关联，增加了关于抑郁和疼痛同时发生的现有文献。
