Kortebein Patrick, Symons T Brock, Ferrando Arny, Paddon-Jones Douglas, Ronsen Ola, Protas Elizabeth, Conger Scott, Lombeida Juan, Wolfe Robert, Evans William J
University of Arkansas for Medical Sciences, Little Rock, AR, USA.
J Gerontol A Biol Sci Med Sci. 2008 Oct;63(10):1076-81. doi: 10.1093/gerona/63.10.1076.
Many older individuals decline functionally during hospitalization, and the deleterious consequences of bed rest may be one cause. This study reports on the effect of 10 days of bed rest on multiple functional parameters in healthy older adults.
Healthy older men and women (n = 11, 67 +/- 5 years old) remained on bed rest for 10 days continuously, and consumed a eucaloric diet providing the Recommended Dietary Allowance for protein. Measures of lower extremity strength and power, aerobic capacity and physical performance, as well as physical activity were performed before and after bed rest.
All measures of lower extremity strength were significantly lower after bed rest including isotonic knee extensor strength (-13.2 +/- 4.1%, p =.004) and stair-climbing power (-14 +/- 4.1%, p =.01). Maximal aerobic capacity was 12% lower after bed rest (p =.04), whereas measures of physical performance (Short Physical Performance Battery, and a five-item physical performance test) were not significantly different. Voluntary physical activity decreased after bed rest, and the percentage of time spent inactive increased (7.6 +/- 1.8%, p =.004). There were no medical complications.
In healthy older adults, 10 days of bed rest results in a substantial loss of lower extremity strength, power, and aerobic capacity, and a reduction in physical activity, but has no effect on physical performance. Identification of interventions to maintain muscle function during hospitalization or periods of bed rest in older adults should be a high priority.
许多老年人在住院期间功能会下降，卧床休息的有害影响可能是原因之一。本研究报告了10天卧床休息对健康老年人多个功能参数的影响。
健康的老年男性和女性（n = 11，67±5岁）连续卧床休息10天，并摄入提供蛋白质推荐膳食摄入量的等热量饮食。在卧床休息前后进行下肢力量和功率、有氧能力和身体表现以及身体活动的测量。
卧床休息后，所有下肢力量测量值均显著降低，包括等张膝关节伸肌力量（-13.2±4.1%，p = 0.004）和爬楼梯功率（-14±4.1%，p = 0.01）。卧床休息后最大有氧能力降低了12%（p = 0.04），而身体表现测量值（简短身体表现量表和五项身体表现测试）无显著差异。卧床休息后自愿身体活动减少，不活动时间百分比增加（7.6±1.8%，p = 0.004）。没有出现医学并发症。
在健康老年人中，10天卧床休息会导致下肢力量、功率和有氧能力大幅丧失，身体活动减少，但对身体表现没有影响。确定在老年人住院期间或卧床休息期间维持肌肉功能的干预措施应是高度优先事项。
