McPartland John M
Department of Osteopathic Manipulative Medicine at Michigan State University College of Osteopathic Medicine in East Lansing, USA.
J Am Osteopath Assoc. 2008 Oct;108(10):586-600. doi: 10.7556/jaoa.2008.108.10.586.
The present review provides an update on endocannabinoid basic science and clinical studies and proposes a new model to describe reciprocal interactions between somatic dysfunction and the endocannabinoid system. The endocannabinoid system consists of cannabinoid receptors, endogenous ligands, and ligand-metabolizing enzymes. The system exemplifies the osteopathic principle that the body possesses self-regulatory mechanisms that are self-healing in nature. Enhancing endocannabinoid activity has broad therapeutic potential, including the treatment of patients with somatic dysfunction, chronic pain, and neurodegenerative diseases as well as inflammatory conditions, bowel dysfunctions, and psychological disorders. Blockade of the endocannabinoid system with drugs such as rimonabant and taranabant may oppose self-healing mechanisms and elicit adverse effects. Osteopathic physicians wield several tools that can augment endocannabinoid activity, including lifestyle modifications, pharmaceutical approaches, and osteopathic manipulative treatment.
本综述提供了内源性大麻素基础科学和临床研究的最新进展，并提出了一个新模型来描述躯体功能障碍与内源性大麻素系统之间的相互作用。内源性大麻素系统由大麻素受体、内源性配体和配体代谢酶组成。该系统体现了整骨疗法的原则，即身体具有本质上自我修复的自我调节机制。增强内源性大麻素活性具有广泛的治疗潜力，包括治疗躯体功能障碍、慢性疼痛、神经退行性疾病以及炎症性疾病、肠道功能障碍和心理障碍患者。使用利莫那班和塔那那班等药物阻断内源性大麻素系统可能会对抗自我修复机制并引发不良反应。整骨疗法医生有多种可以增强内源性大麻素活性的工具，包括生活方式改变、药物治疗方法和整骨手法治疗。
