Buonomini Caterina, Bonetti Oliviero, Novelli Emanuele
Osteopathic, Biological, Medical Research, Omicron Beta Research, Roma, ITA.
Facoltà di Medicina e Chirurgia, Università di Roma Tor Vergata, Roma, ITA.
Cureus. 2024 Feb 24;16(2):e54848. doi: 10.7759/cureus.54848. eCollection 2024 Feb.
The endocannabinoid system is an important neuromodulatory system responsible for maintaining homeostasis in the biological system. Similarly, the autonomic nervous system is important to control involuntary bodily functions such as thermoregulation, regulation of heart rate and sleep latency. The endocannabinoid system and the autonomic nervous system can be modified by osteopathic manipulative techniques. In this report, we present a case of a 53-year-old patient with comorbidities, habitual cannabis use, and disorders associated with the endocannabinoid system and autonomic nervous system, on whom the cranial technique of the fourth ventricle (CV4) was performed. The results obtained from the Pittsburgh Questionnaire and the Health Survey 36 (SF-36) Questionnaire were encouraging. The patient decreased tetrahydrocannabinol (THC) consumption. Her sleep quality and health improved, thus improving her quality of life. CV4 aimed to influence the functioning of the patient's autonomic nervous system and consequently the endocannabinoid system. Further research using randomized controlled trials will be important to have measurable and objective data on this topic.
内源性大麻素系统是一个重要的神经调节系统，负责维持生物系统的稳态。同样，自主神经系统对于控制诸如体温调节、心率调节和睡眠潜伏期等非自主身体功能也很重要。内源性大麻素系统和自主神经系统可以通过整骨手法技术进行调节。在本报告中，我们介绍了一例53岁的患者，该患者患有多种合并症，有长期使用大麻的习惯，且患有与内源性大麻素系统和自主神经系统相关的疾病，对其实施了第四脑室颅骨技术（CV4）。从匹兹堡问卷和健康调查36项（SF-36）问卷中获得的结果令人鼓舞。患者减少了四氢大麻酚（THC）的摄入量。她的睡眠质量和健康状况得到改善，从而提高了生活质量。CV4旨在影响患者自主神经系统的功能，进而影响内源性大麻素系统。使用随机对照试验进行进一步研究对于获得关于该主题的可测量和客观数据非常重要。
