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特发性正常压力脑积水患者可编程压力阀设置快速参考表的编制

Development of a quick reference table for setting programmable pressure valves in patients with idiopathic normal pressure hydrocephalus.

作者信息

Miyake Hiroji, Kajimoto Yoshinaga, Tsuji Masao, Ukita Tohru, Tucker Adam, Ohmura Takehisa

机构信息

Nishinomiya Kyoritsu Neurosurgical Hospital, Nishinomiya, Hyogo, Japan.

出版信息

Neurol Med Chir (Tokyo). 2008 Oct;48(10):427-32; discussion 432. doi: 10.2176/nmc.48.427.

DOI:10.2176/nmc.48.427
PMID:18948675
Abstract

Quick and reliable setting of programmable pressure valves (PPVs) is important in the treatment of idiopathic normal pressure hydrocephalus (iNPH), especially for reducing overdrainage complications and related medical costs. A new quick reference table (QRT) was developed for improved PPV control and outcome. Shunt control can be based on the pressure environment in the sitting condition, given as hydrostatic pressure (HP) = intracranial pressure + PPV setting + intraabdominal pressure (IAP). Using this relationship, and estimating HP and IAP from the patient's height and body mass index, respectively, a QRT was designed, consisting of a matrix of the patient's height and weight. The QRT was used to make initial PPV settings in 25 patients with iNPH and the clinical outcomes were evaluated. Postoperative readjustments of the PPV were not necessary in 15 of the 25 patients. At 1 month after operation, the PPV setting was decreased once in 5 patients and increased once in 2 patients. Four of these 7 patients improved after a single readjustment. Three patients required further readjustments. At 3 months after operation, another 3 patients required a single readjustment and all improved after this readjustment. The readjustment rate was 40% and readjustment number was 0.68 times/patient. The mean PPV setting at 1 year after operation was 15.5 +/- 3.9 cmH(2)O. Use of the QRT in non-bedridden iNPH patients results in a low incidence of PPV readjustment.

摘要

快速且可靠地设置可编程压力阀(PPV)在特发性正常压力脑积水(iNPH)的治疗中至关重要,特别是对于减少过度引流并发症及相关医疗费用。为改善PPV控制及治疗效果,开发了一种新的快速参考表(QRT)。分流控制可基于坐位时的压力环境,即静水压力(HP)=颅内压+PPV设置+腹腔内压力(IAP)。利用这种关系,并分别根据患者身高和体重指数估算HP和IAP,设计了一个由患者身高和体重组成矩阵的QRT。该QRT用于对25例iNPH患者进行初始PPV设置,并评估临床结果。25例患者中有15例术后无需对PPV进行重新调整。术后1个月,5例患者PPV设置降低了一次,2例患者升高了一次。这7例患者中有4例在单次重新调整后病情改善。3例患者需要进一步重新调整。术后3个月,又有3例患者需要单次重新调整,且所有患者在此次重新调整后均有所改善。重新调整率为40%,重新调整次数为0.68次/患者。术后1年的平均PPV设置为15.5±3.9 cmH₂O。在非卧床iNPH患者中使用QRT可使PPV重新调整的发生率较低。

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