低高密度脂蛋白胆固醇、吸烟与IL-13 R130Q基因多态性与塞浦路斯希腊裔男性心肌梗死有关。一项初步研究。
Low HDL cholesterol, smoking and IL-13 R130Q polymorphism are associated with myocardial infarction in Greek Cypriot males. A pilot study.
作者信息
Xenophontos Stavroulla, Hadjivassiliou Marilena, Karagrigoriou Alexandros, Demetriou Nafsika, Miltiadous George, Marcou Ioannis, Elisaf Moses, Mikhailidis Dimitri P, Cariolou Marios A
机构信息
Department of Cardiovascular Genetics & The Laboratory of Forensic Genetics, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
出版信息
Open Cardiovasc Med J. 2008;2:52-9. doi: 10.2174/1874192400802010052. Epub 2008 Jul 22.
This study was carried out in Greek Cypriot males to identify risk factors that predispose to myocardial infarction (MI). Genetic and lipid risk factors were investigated for the first time in a Greek Cypriot male case-control study.Contrary to other studies, mean low density lipoprotein cholesterol did not differ between cases and controls. High density lipoprotein cholesterol on the other hand, although within normal range in cases and controls, was significantly higher in the control population. In agreement with many other studies, smoking was significantly more prevalent in cases compared with controls. In pooled cases and controls, smokers had a significantly lower HDL-C level compared with non-smokers. The frequency of the IL-13 R130Q homozygotes for the mutation (QQ), as well as the mutant allele were significantly higher in cases compared with controls. The IL-13 R130Q variant, or another locus, linked to it, may increase the risk of MI.
本研究在塞浦路斯希腊族男性中开展，以确定易患心肌梗死（MI）的风险因素。在一项塞浦路斯希腊族男性病例对照研究中，首次对遗传和血脂风险因素进行了调查。与其他研究相反，病例组和对照组的平均低密度脂蛋白胆固醇没有差异。另一方面，高密度脂蛋白胆固醇虽然在病例组和对照组中均处于正常范围内，但在对照组人群中显著更高。与许多其他研究一致，病例组中吸烟的比例显著高于对照组。在合并的病例组和对照组中，吸烟者的高密度脂蛋白胆固醇水平显著低于非吸烟者。与对照组相比，病例组中白细胞介素-13 R130Q突变纯合子（QQ）的频率以及突变等位基因的频率显著更高。白细胞介素-13 R130Q变体或与之相关的另一个基因座可能会增加心肌梗死的风险。
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