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代谢综合征及其组分的知晓率、治疗与控制:一项希腊多中心研究。

Awareness, treatment and control of the metabolic syndrome and its components: a multicentre Greek study.

作者信息

Athyros Vasilios G, Ganotakis Emmanuel S, Bathianaki Maria, Monedas Ioannis, Goudevenos Ioannis A, Papageorgiou Athanasios A, Papathanasiou Athanasios, Kakafika Anna I, Mikhailidis Dimitri P, Elisaf Moses

机构信息

Atherosclerosis and Metabolic Syndrome Units, 2nd Prop. Department of Internal Medicine, Aristotelian University, Hippocration Hospital, Thessaloniki, Greece.

出版信息

Hellenic J Cardiol. 2005 Nov-Dec;46(6):380-6.

Abstract

INTRODUCTION

There are no data concerning the degree of awareness, treatment and control of the metabolic syndrome (MetS) and its components or associated vascular risk in the general population.

METHODS

A cross-sectional analysis was made of a representative sample of Greek adults (n=9669, 49% men and 51% women), living in urban, semi-urban and rural areas (55%, 23% and 22%, respectively). The National Cholesterol Education Program (NCEP-ATP III) and the International Diabetes Federation (IDF) definitions for the MetS were used.

RESULTS

The age-standardised prevalence of the MetS in the general population was 24.5% [95% CI 23.4-25.7%] (n=2369). This was similar in men and women and increased with age. Among subjects with the NCEP MetS the prevalence of hypertension was 71%, elevated blood glucose 55%, low high-density lipoprotein cholesterol 58%, high triglycerides 63% and abdominal obesity 82%. Only one third of subjects were aware of the MetS component conditions, less than one quarter were on treatment, and very few (< or =10%) were controlled for MetS components. Awareness of MetS individual component conditions (e.g. arterial hypertension), and consequently effective control, was lower than that reported in other cohorts, including subjects without MetS. Only 5% of subjects were aware of MetS as an entity, 2% were treated for all component conditions and only 1% were controlled. Using the IDF definition, the prevalence of MetS was higher (43.4%) and awareness, treatment and control of MetS and its components were significantly lower.

CONCLUSIONS

The prevalence of MetS is high in Greece but is not recognised among the general population. Therefore, treatment and control of MetS and component conditions are extremely low. If the situation does not improve soon, MetS will cause a further increase in the vascular disease epidemic in the years to come. This calls for urgent education of the public and the medical community.

摘要

引言

目前尚无关于一般人群中代谢综合征(MetS)及其各组分的知晓程度、治疗及控制情况,或相关血管风险的数据。

方法

对居住在城市、半城市和农村地区(分别占55%、23%和22%)的希腊成年人代表性样本(n = 9669,男性占49%,女性占51%)进行横断面分析。采用美国国家胆固醇教育计划(NCEP - ATP III)和国际糖尿病联盟(IDF)对MetS的定义。

结果

一般人群中MetS的年龄标准化患病率为24.5% [95%可信区间23.4 - 25.7%](n = 2369)。男女患病率相似且随年龄增加。在符合NCEP MetS标准的受试者中,高血压患病率为71%,血糖升高为55%,高密度脂蛋白胆固醇降低为58%,甘油三酯升高为63%,腹型肥胖为82%。只有三分之一的受试者知晓MetS的组分情况,不到四分之一接受治疗,且很少有人(≤10%)的MetS组分得到控制。对MetS单个组分情况(如动脉高血压)的知晓率,以及相应的有效控制率,低于其他队列报道的情况,包括无MetS的受试者。只有5%的受试者知晓MetS这一整体情况,2%针对所有组分情况接受治疗,仅1%得到控制。采用IDF定义时,MetS患病率更高(43.4%),且对MetS及其组分的知晓、治疗和控制显著更低。

结论

MetS在希腊患病率很高,但在一般人群中未得到认识。因此,对MetS及其组分情况的治疗和控制极低。如果情况不能很快改善,MetS将在未来几年导致血管疾病流行进一步加剧。这需要对公众和医学界进行紧急教育。

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