Forte Franklin Delano Soares, Moimaz Suzely Adas Saliba, Sampaio Fábio Correia
Department of Pediatric and Community Dentistry, Dental School of Araçatuba, São Paulo State University, Araçatuba, SP, Brazil.
Braz Dent J. 2008;19(3):214-8. doi: 10.1590/s0103-64402008000300007.
The aim of this study was to evaluate the urinary fluoride excretion of 2- to 7-year-old children exposed to different water fluoride concentrations in the city of Catolé do Rocha, PB, Brazil. Forty-two children were allocated to 3 groups according to the concentration of fluoride in the water: G1 (n=10; 0.5-1.0 ppm F), G2 (n=17; 1.1-1.5 ppm F) and G3 (n= 15; >1.51 ppm F). The study was carried out in two 1-week phases with 1-month interval between the moments of data collection: in the first phase, the children used a fluoride toothpaste (FT) (1,510 ppm F) for 1 week, whereas in the second phase a non-fluoride toothpaste (NFT) was used. The urine was collected in a 24-h period in each week-phase according to Marthaler's protocol. The urinary fluoride excretion data expressed as mean (SD) in microg/24 h were: G1-FT= 452.9 (290.2); G1-NFT= 435.1 (187.0); G2-FT= 451.4 (224.0); G2-NFT= 430.3 (352.5); G3-FT=592.3 (390.5); and G3-NFT=623.6 (408.7). There was no statistically significant difference between the water fluoride groups, and regardless of the week phase (ANOVA, p>0.05). The use of fluoride toothpaste (1,510 ppmF) did not promote an increase in urinary fluoride excretion. There was a trend, though not significant, as to the increase of urine fluoride concentration in relation to fluoride concentrations in the water. The excretion values suggest that some children are under risk to develop dental fluorosis and information about the appropriate use of fluoride is necessary in this area.
本研究旨在评估巴西帕拉伊巴州卡托莱杜罗查市2至7岁儿童在接触不同氟浓度饮用水时的尿氟排泄情况。根据水中氟浓度，42名儿童被分为3组：G1组（n = 10；0.5 - 1.0 ppm F），G2组（n = 17；1.1 - 1.5 ppm F）和G3组（n = 15；>1.51 ppm F）。该研究分两个为期1周的阶段进行，数据收集时刻之间间隔1个月：在第一阶段，儿童使用含氟牙膏（FT）（1,510 ppm F）1周，而在第二阶段使用无氟牙膏（NFT）。根据马特勒尔方案，在每个为期1周的阶段中，收集24小时尿液。尿氟排泄数据以微克/24小时的平均值（标准差）表示为：G1 - FT = 452.9（290.2）；G1 - NFT = 435.1（187.0）；G2 - FT = 451.4（224.0）；G2 - NFT = 430.3（352.5）；G3 - FT = 592.3（390.5）；G3 - NFT = 623.6（408.7）。不同水氟组之间无统计学显著差异，且与周阶段无关（方差分析，p>0.05）。使用含氟牙膏（1,510 ppm F）并未促进尿氟排泄增加。尽管不显著，但尿氟浓度有随水中氟浓度增加的趋势。排泄值表明一些儿童有患氟斑牙的风险，在该地区有必要提供关于氟正确使用的信息。
