Ketley C E, Lennon M A
Department of Clinical Dental Sciences, University of Liverpool School of Dentistry, Liverpool L69 3BX, UK.
Int J Paediatr Dent. 2000 Dec;10(4):260-70. doi: 10.1046/j.1365-263x.2000.00208.x.
To determine fluoride excretion under various conditions of fluoride intake and to estimate the fractional urinary excretion of fluoride in individual children participating in a school milk fluoridation scheme.
In the first part of the study, individual urine samples were collected from each of eight 4 to 5-year-old children for a continuous period of 55 h. For each child (n = 8) and for each day (n = 3) the maximum urinary fluoride concentration (p.p.m.F), the maximum fluoride excretion rate (microgram F/h) and the total daily fluoride excretion (mg) were calculated. The second part of the study was carried out to determine the 24 h fractional percentage of fluoride excreted following administration of a known dose of fluoride in the absence of other sources.
Under usual conditions of fluoride intake (i.e. milk containing 0.5 mg fluoride, customary diet and toothbrushing with fluoride toothpaste) the children's daily fluoride excretion was 0.33 mg. The fractional urinary fluoride excretion of a 0.5-mg fluoride tablet was 30%.
It is concluded that the children's mean 24 h fluoride excretion was somewhere between that reported in low fluoride conditions and that reported in optimally fluoridated areas. The fractional urinary fluoride excretion was found to be in agreement with the findings of other workers.
确定在不同氟摄入量条件下的氟排泄情况，并估算参与学校牛奶氟化项目的个体儿童尿氟的排泄分数。
在研究的第一部分，连续55小时从8名4至5岁儿童中每人采集个体尿液样本。针对每个儿童（n = 8）和每一天（n = 3），计算最大尿氟浓度（ppmF）、最大氟排泄率（微克F/小时）和每日总氟排泄量（毫克）。研究的第二部分是在没有其他氟来源的情况下，给予已知剂量的氟后，测定24小时氟排泄的分数百分比。
在通常的氟摄入条件下（即饮用含0.5毫克氟的牛奶、日常饮食以及使用含氟牙膏刷牙），儿童每日氟排泄量为0.33毫克。一片0.5毫克氟片的尿氟排泄分数为30%。
得出的结论是，儿童24小时平均氟排泄量介于低氟条件下报告的数值和最佳氟化地区报告的数值之间。发现尿氟排泄分数与其他研究人员的结果一致。
