Cury Patricia Ramos, Furuse Cristiane, Rodrigues Ana Elisa Amaro, Barbuto José Alexandre, Araújo Vera Cavalcanti de, Araújo Ney Soares de
Department of Microbiology, São Leopoldo Mandic Dental Reseach Center, Campinas, SP, Brazil.
Braz Oral Res. 2008 Jul-Sep;22(3):258-63. doi: 10.1590/s1806-83242008000300012.
The aim of the present study was to compare quantitatively the distribution of dendritic cell subpopulations in chronic periodontitis and gingivitis. Fourteen biopsies from patients with chronic periodontitis and fifteen from patients with gingivitis were studied. An immunoperoxidase technique was used to quantify the number of Langerhans' cells (CD1a) and interstitial dendritic cells (factor XIIIa) in the oral and sulcular and junctional/pocket epithelia and in the lamina propria. A greater number of factor XIIIa+ dendritic cells in the lamina propria and CD1a+ dendritic cells in the oral epithelium were observed in gingivitis compared to the periodontitis group (p = 0.05). In the sulcular and junctional/pocket epithelia and in the lamina propria, the number of CD1a+ dendritic cells was similar in the gingivitis and periodontitis groups. In conclusion, the number of Langerhans' cells in the oral epithelium and interstitial dendritic cells in the lamina propria is increased in gingivitis compared to periodontitis, which may contribute to the different pattern of host response in these diseases.
本研究的目的是定量比较慢性牙周炎和牙龈炎中树突状细胞亚群的分布。研究了14例慢性牙周炎患者的活检组织和15例牙龈炎患者的活检组织。采用免疫过氧化物酶技术对口腔、龈沟和结合上皮/袋状上皮以及固有层中朗格汉斯细胞（CD1a）和间质树突状细胞（因子XIIIa）的数量进行定量。与牙周炎组相比，牙龈炎组固有层中因子XIIIa+树突状细胞和口腔上皮中CD1a+树突状细胞数量更多（p = 0.05）。在龈沟和结合上皮/袋状上皮以及固有层中，牙龈炎组和牙周炎组CD1a+树突状细胞数量相似。总之，与牙周炎相比，牙龈炎患者口腔上皮中朗格汉斯细胞和固有层中间质树突状细胞数量增加，这可能导致这些疾病中宿主反应的不同模式。
