Addiss D G, Davis J P, Meade B D, Burstyn D G, Meissner M, Zastrow J A, Berg J L, Drinka P, Phillips R
Acute and Communicable Disease Epidemiology Section, Wisconsin Division of Health, Madison 53701-0309.
J Infect Dis. 1991 Oct;164(4):704-10. doi: 10.1093/infdis/164.4.704.
The epidemiologic features and clinical spectrum of pertussis in the elderly are poorly understood. In October 1985, the Wisconsin Division of Health investigated an outbreak of pertussis in residents of a nursing home in rural Wisconsin. Clinical information and nasopharyngeal swab and acute- and convalescent-phase serum specimens were obtained from all consenting residents and employees. Of 105 residents, 38 (36.2%) were seropositive, including four who were culture-positive for Bordetella pertussis. Culture-positive residents (age range, 52-81 years) had cough lasting 43-54 days. Three of these residents had paroxysmal cough, and all four had cough that interrupted sleep; none of the residents had cough with apnea or vomiting, and all recovered without sequelae. Of six seropositive residents with clinical pertussis, five lived on the south wing of the facility. Of 104 employees, 8 (7.7%) were seropositive, but none were culture-positive for B. pertussis. The higher attack rate for residents and the clustering of clinical cases were consistent with ongoing transmission within the nursing home.
老年人百日咳的流行病学特征和临床谱尚不清楚。1985年10月，威斯康星州卫生部门对威斯康星州农村一家养老院居民中的百日咳疫情进行了调查。从所有同意参与的居民和员工那里获取了临床信息、鼻咽拭子以及急性期和恢复期血清标本。在105名居民中，38人（36.2%）血清学呈阳性，其中4人百日咳博德特氏菌培养呈阳性。培养呈阳性的居民（年龄范围52 - 81岁）咳嗽持续43 - 54天。这些居民中有3人出现阵发性咳嗽，4人咳嗽均影响睡眠；所有居民均无伴有呼吸暂停或呕吐的咳嗽，且全部康复，无后遗症。在6名临床诊断为百日咳的血清学阳性居民中，有5人住在该机构的南翼。在104名员工中，8人（7.7%）血清学呈阳性，但无人百日咳博德特氏菌培养呈阳性。居民中较高的发病率以及临床病例的聚集与养老院内部的持续传播一致。
