Group Practice & Center, Allergy, Respiratory and Sleep Medicine, Maingau Hospital of the Red Cross, Frankfurt am Main, Germany.
Life and Health Sciences Research Institute, School of Medicine, University of Minho School of Medicine, Braga, Portugal.
Hum Vaccin Immunother. 2024 Dec 31;20(1):2324547. doi: 10.1080/21645515.2024.2324547. Epub 2024 Apr 2.
Pertussis has several notable consequences, causing economic burden, increased strain on healthcare facilities, and reductions in quality of life. Recent years have seen a trend toward an increase in pertussis cases affecting older children and adults. To boost immunity, and protect vulnerable populations, an enduring approach to vaccination has been proposed, but gaps remain in the evidence surrounding adult vaccination that are needed to inform such a policy. Gaps include: the true incidence of pertussis and its complications in adults; regional variations in disease recognition and reporting; and incidence of severe disease, hospitalizations, and deaths in older adults. Better data on the efficacy/effectiveness of pertussis vaccination in adults, duration of protection, and factors leading to poor vaccine uptake are needed. Addressing the critical evidence gaps will help highlight important areas of unmet need and justify the importance of adult pertussis vaccination to healthcare professionals, policymakers, and payers.
百日咳有几个显著的后果，导致经济负担加重、医疗设施压力增大以及生活质量下降。近年来，儿童和成人百日咳病例呈上升趋势。为了增强免疫力，保护弱势群体，人们提出了一种持久的疫苗接种方法，但在成人疫苗接种方面，仍存在一些需要的证据空白，以提供这种政策的信息。空白包括：成人百日咳及其并发症的真实发病率；疾病识别和报告的区域差异；以及老年人患重病、住院和死亡的发病率。需要更好的关于成人百日咳疫苗接种的疗效/效果、保护持续时间以及导致疫苗接种率低的因素的数据。解决这些关键的证据空白将有助于突出未满足需求的重要领域，并使医疗保健专业人员、政策制定者和支付方认识到成人百日咳疫苗接种的重要性。
