MacIntyre C Raina, de Sousa Jaime Correia, Heininger Ulrich, Kardos Peter, Konstantopoulos Andreas, Middleton Donald, Nolan Terry, Papi Alberto, Rendon Adrian, Rizzo Albert, Sampson Kim, Sette Alessandro, Sobczyk Elizabeth, Tan Tina, Weil-Olivier Catherine, Weinberger Birgit, Wilkinson Tom, von König Carl Heinz Wirsing
Kirby Institute, University of New South Wales, Sydney, Australia.
School of Medicine, University of Minho, Braga, Portugal.
Hum Vaccin Immunother. 2024 Dec 31;20(1):2377904. doi: 10.1080/21645515.2024.2377904. Epub 2024 Jul 17.
A panel of 24 international experts met in July 2022 to discuss challenges associated with pertussis detection, monitoring, and vaccination in adults; conclusions from this meeting are presented. There has been a shift in the epidemiology of pertussis toward older children and adults. This shift has been attributed to the waning of infection- or vaccine-induced immunity, newer detection techniques causing detection bias, and possibly the replacement of whole-cell pertussis with acellular vaccines in high-income countries, which may lead to immunity waning more quickly. The burden of adult pertussis is still likely under-ascertained due to widespread under-recognition by healthcare professionals (HCPs), under-diagnosis, and under-reporting in this age group. Non-standardized testing guidance and varied case definitions have contributed to under-reporting. Key barriers to HCP engagement with the tetanus, diphtheria, and pertussis (Tdap) vaccine include low awareness, lack of time/funding, and lack of motivation due to low prioritization of Tdap.
2022年7月，一个由24名国际专家组成的小组召开会议，讨论成人百日咳检测、监测和疫苗接种方面的相关挑战；本文介绍了此次会议的结论。百日咳的流行病学已转向大龄儿童和成人。这种转变归因于感染或疫苗诱导的免疫力减弱、新的检测技术导致检测偏差，以及高收入国家可能用无细胞疫苗取代全细胞百日咳疫苗，这可能导致免疫力更快减弱。由于医疗保健专业人员（HCP）普遍认识不足、诊断不足以及该年龄组报告不足，成人百日咳的负担可能仍未得到充分确认。非标准化检测指南和不同的病例定义导致了报告不足。HCP接种破伤风、白喉和百日咳（Tdap）疫苗的主要障碍包括认识不足、缺乏时间/资金以及由于Tdap优先级低而缺乏动力。
