Choi Sang-Hyun, Na Hyon Bin, Park Yong Il, An Kwangjin, Kwon Soon Gu, Jang Youngjin, Park Mi-Hyun, Moon Jaewon, Son Jae Sung, Song In Chan, Moon Woo Kyung, Hyeon Taeghwan
National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea.
J Am Chem Soc. 2008 Nov 19;130(46):15573-80. doi: 10.1021/ja805311x. Epub 2008 Oct 25.
Heterostructured nanoparticles composed of metals and Fe3O4 or MnO were synthesized by thermal decomposition of mixtures of metal-oleate complexes (for the oxide component) and metal-oleylamine complexes (for the metal component). The products included flowerlike-shaped nanoparticles of Pt-Fe3O4 and Ni-Fe3O4 and snowmanlike-shaped nanoparticles of Ag-MnO and Au-MnO. Powder X-ray diffraction patterns showed that these nanoparticles were composed of face-centered cubic (fcc)-structured Fe3O4 or MnO and fcc-structured metals. The relaxivity values of the Au-MnO and Au-Fe3O4 nanoparticles were similar to those of the MnO and Fe3O4 nanoparticles, respectively. Au-Fe3O4 heterostructured nanoparticles conjugated with two kinds of 12-base oligonucleotide sequences were able to sense a complementary 24-mer sequence, causing nanoparticle aggregation. This hybridization-mediated aggregation was detected by the overall size increase indicated by dynamic light scattering data, the red shift of the surface plasmon band of the Au component, and the enhancement of the signal intensity of the Fe3O4 component in T2-weighted magnetic resonance imaging.
通过热分解金属油酸盐配合物（用于氧化物组分）和金属油胺配合物（用于金属组分）的混合物，合成了由金属与Fe₃O₄或MnO组成的异质结构纳米颗粒。产物包括Pt-Fe₃O₄和Ni-Fe₃O₄的花状纳米颗粒以及Ag-MnO和Au-MnO的雪人状纳米颗粒。粉末X射线衍射图谱表明，这些纳米颗粒由面心立方（fcc）结构的Fe₃O₄或MnO以及fcc结构的金属组成。Au-MnO和Au-Fe₃O₄纳米颗粒的弛豫率值分别与MnO和Fe₃O₄纳米颗粒的弛豫率值相似。与两种12碱基寡核苷酸序列共轭的Au-Fe₃O₄异质结构纳米颗粒能够检测互补的24聚体序列，导致纳米颗粒聚集。通过动态光散射数据表明的整体尺寸增加、Au组分表面等离子体带的红移以及T2加权磁共振成像中Fe₃O₄组分信号强度的增强来检测这种杂交介导的聚集。
