胆固醇代谢细胞色素P450：对降低胆固醇的意义。
Cholesterol-metabolizing cytochromes P450: implications for cholesterol lowering.
作者信息
Pikuleva Irina A
机构信息
Case Western Reserve University, University Hospitals Case Medical Center, Department of Ophthalmology and Visual Sciences, Cleveland, OH 44106, USA.
出版信息
Expert Opin Drug Metab Toxicol. 2008 Nov;4(11):1403-14. doi: 10.1517/17425255.4.11.1403.
Abstract
Cardiovascular disease (CVD) continues to be a leading cause of death worldwide. Elevated serum cholesterol is one of the classical risk factors for CVD, which also include age, hypertension, smoking, diabetes mellitus, obesity and family history. Several therapeutic drug classes have been developed to treat hypercholesterolemia; yet, an important percentage of patients do not reach their treatment goals. Therefore, new cholesterol-lowering medications that have sites of action different from that of drugs available at present need to be developed. This review summarizes new information about cytochrome P450 enzymes 7A1, 27A1 and 46A1. These enzymes play key roles in cholesterol elimination and have the potential to serve as targets for cholesterol-lowering.
摘要
心血管疾病（CVD）仍然是全球主要的死亡原因之一。血清胆固醇升高是心血管疾病的经典危险因素之一，其他危险因素还包括年龄、高血压、吸烟、糖尿病、肥胖和家族病史。已经开发了几类治疗药物来治疗高胆固醇血症；然而，仍有相当一部分患者未达到治疗目标。因此，需要开发作用位点与现有药物不同的新型降胆固醇药物。这篇综述总结了关于细胞色素P450酶7A1、27A1和46A1的新信息。这些酶在胆固醇消除中起关键作用，并有潜力作为降胆固醇的靶点。
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