Rascol O, Sabatini U, Simonetta-Moreau M, Montastruc J L, Rascol A, Clanet M
University Hospital, Toulouse, France.
J Neurol Neurosurg Psychiatry. 1991 Jul;54(7):599-602. doi: 10.1136/jnnp.54.7.599.
The frequency of square wave jerks (SWJ) was compared in eight patients with progressive supranuclear palsy (PSP), 25 patients with multiple system atrophy or Parkinson's disease plus (MSA/PP), 85 patients with idiopathic Parkinson's disease (PD) and 20 age-matched normal volunteers. In the control group, the mean (SD) SWJ frequency (SWJ larger than 1 degree amplitude) was 2.3 (2.4)/min. Abnormal ocular fixation (SWJ frequency greater than 10/min) was observed in a large proportion of PSP patients (7/8) and of MSA/PP patients (16/25) but in few PD patients (13/85). In the group of PD patients with abnormal ocular fixation, freezing of gait, falls and instability were more severe than in the group of PD patients with normal fixation. The study of ocular fixation may help to differentiate PD clinically from other Parkinsonian syndromes. SWJ are probably not related to the central degeneration of the dopaminergic nigrostriatal pathway observed in PD.
对8例进行性核上性麻痹（PSP）患者、25例多系统萎缩或帕金森叠加综合征（MSA/PP）患者、85例特发性帕金森病（PD）患者以及20名年龄匹配的正常志愿者的方波急跳（SWJ）频率进行了比较。在对照组中，平均（标准差）SWJ频率（振幅大于1度的SWJ）为2.3（2.4）次/分钟。在大部分PSP患者（7/8）和MSA/PP患者（16/25）中观察到异常眼球注视（SWJ频率大于10次/分钟），但在少数PD患者（13/85）中观察到。在有异常眼球注视的PD患者组中，步态冻结、跌倒和不稳定性比眼球注视正常的PD患者组更严重。对眼球注视的研究可能有助于在临床上将PD与其他帕金森综合征区分开来。SWJ可能与PD中观察到的多巴胺能黑质纹状体通路的中枢变性无关。
