Russell Lucy L, Greaves Caroline V, Convery Rhian S, Bocchetta Martina, Warren Jason D, Kaski Diego, Rohrer Jonathan D
Dementia Research Centre, Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology London UK.
Centre for Vestibular and Behavioural Neurosciences, Department of Clinical and Motor Neurosciences UCL Queen Square Institute of Neurology London UK.
Alzheimers Dement (N Y). 2021 Dec 31;7(1):e12218. doi: 10.1002/trc2.12218. eCollection 2021.
Oculomotor function has not been systematically studied in frontotemporal dementia (FTD) and yet may offer a simple target to monitor disease activity.
We assessed fixation stability, smooth pursuit, pro-saccades, and anti-saccades using the Eyelink 1000-plus eye-tracker in 19 individuals with behavioral variant FTD (bvFTD) and 22 controls. Neuroanatomical correlates were assessed using a region of interest magnetic resonance imaging (MRI) analysis.
Measures of fixation stability were impaired in the bvFTD group compared with controls. However, performance did not differ from controls in the pro-saccade tasks except in the vertical overlap condition. The bvFTD group performed worse in the anti-saccade task, which correlated strongly with executive function. Neural correlates included the orbitofrontal and ventromedial prefrontal cortices and striatum for fixation stability, and the dorsolateral prefrontal and parietal cortices and striatum for anti-saccades.
Overall, oculomotor function is abnormal in bvFTD, with performance likely related to impairment of inhibitory control and executive dysfunction.
额颞叶痴呆（FTD）中的眼球运动功能尚未得到系统研究，但它可能是监测疾病活动的一个简单指标。
我们使用Eyelink 1000 plus眼动仪对19例行为变异型FTD（bvFTD）患者和22名对照者的注视稳定性、平稳跟踪、顺向扫视和逆向扫视进行了评估。使用感兴趣区磁共振成像（MRI）分析评估神经解剖学相关性。
与对照组相比，bvFTD组的注视稳定性指标受损。然而，除了垂直重叠条件外，顺向扫视任务中的表现与对照组没有差异。bvFTD组在逆向扫视任务中表现更差，这与执行功能密切相关。神经相关性包括眶额叶和腹内侧前额叶皮质以及纹状体与注视稳定性有关，而背外侧前额叶和顶叶皮质以及纹状体与逆向扫视有关。
总体而言，bvFTD患者的眼球运动功能异常，其表现可能与抑制控制受损和执行功能障碍有关。
