el-Labban N G, Lee K W, Rule D
Institute of Dental Surgery, Eastman Dental Hospital, London, England.
J Oral Pathol Med. 1991 Aug;20(7):352-60. doi: 10.1111/j.1600-0714.1991.tb00944.x.
The changes in a permanent central incisor of a patient suffering from hypophosphatasia, were investigated light microscopically and compared with those of two of his primary teeth. In addition his other central incisor was studied with transmission and scanning EM. The changes in permanent teeth were similar to those of the primary dentition, including loss of cementum and the presence of deep resorption areas in dentin. Afibrillar cementum was detected with EM, and was attached to dentin surface. The presence of a thick layer of bacterial plaque was a prominent feature in all the teeth examined. A large number of bacteria was also found in resorption bays. It is suggested that bacteria may play an important role in the destruction of soft and hard tissues leading to loss of teeth in hypophosphatasia.
对一名患有低磷酸酯酶症患者的一颗恒中切牙的变化进行了光镜检查，并与他的两颗乳牙的变化进行了比较。此外，还对他的另一颗中切牙进行了透射电镜和扫描电镜研究。恒牙的变化与乳牙列的变化相似，包括牙骨质丧失和牙本质中存在深部吸收区。通过电镜检测到无纤维牙骨质，并附着在牙本质表面。在所检查的所有牙齿中，厚层菌斑的存在是一个突出特征。在吸收窝中也发现了大量细菌。提示细菌可能在低磷酸酯酶症导致牙齿丧失的软硬组织破坏中起重要作用。
