Goedert Michel
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.
Brain. 2009 Apr;132(Pt 4):1102-11. doi: 10.1093/brain/awn256. Epub 2008 Oct 24.
The centenary of Alois Alzheimer's description of the case of Auguste Deter has renewed interest in the early history of dementia research. In his 1907 paper Alzheimer described the presence of plaques and tangles in one case of presenile dementia. In the same year, Oskar Fischer reported neuritic plaques in 12 cases of senile dementia. These were landmark findings in the history of research in dementia because they delineated the clinicopathological entity that is now known as Alzheimer's disease. Although much has been written about Alzheimer, only little is known about Fischer. The present article discusses Fischer's work on dementia in the context of his life and time.
阿洛伊斯·阿尔茨海默（Alois Alzheimer）对奥古斯特·德特尔（Auguste Deter）病例的描述迎来百年纪念，这重新引发了人们对痴呆症研究早期历史的兴趣。在1907年的论文中，阿尔茨海默描述了一例早老性痴呆症患者存在斑块和缠结。同年，奥斯卡·费舍尔（Oskar Fischer）报告了12例老年性痴呆症患者出现神经炎性斑块。这些是痴呆症研究史上的里程碑式发现，因为它们界定了如今被称为阿尔茨海默病的临床病理实体。尽管关于阿尔茨海默的著述颇多，但对费舍尔却知之甚少。本文在费舍尔的生活背景和所处时代的背景下讨论了他关于痴呆症的研究工作。
