不同的门控模式决定了NMDA受体电流的双相弛豫。
Distinct gating modes determine the biphasic relaxation of NMDA receptor currents.
作者信息
Zhang Wei, Howe James R, Popescu Gabriela K
机构信息
Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520-8066, USA.
出版信息
Nat Neurosci. 2008 Dec;11(12):1373-5. doi: 10.1038/nn.2214. Epub 2008 Oct 26.
Abstract
Following brief stimulation, macroscopic NMDA receptor currents decay with biphasic kinetics that is believed to reflect glutamate dissociation and receptor desensitization. We found that the fast and slow decay components arise from the simultaneous deactivation of receptor populations that gate with short and long openings, respectively. Because individual receptors switched infrequently between gating modes, the relaxation time course was largely determined by the proportion of channels in each gating mode at the time of stimulation.
摘要
短暂刺激后，宏观NMDA受体电流以双相动力学衰减，这种双相动力学被认为反映了谷氨酸解离和受体脱敏。我们发现，快速和慢速衰减成分分别源于具有短开放和长开放的受体群体的同时失活。由于单个受体在门控模式之间很少切换，弛豫时间进程在很大程度上由刺激时每种门控模式下通道的比例决定。
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