N-甲基-D-天冬氨酸受体亚型激活与调节的动力学模型。
Kinetic models for activation and modulation of NMDA receptor subtypes.
作者信息
Iacobucci Gary J, Popescu Gabriela K
机构信息
JSMBS, University at Buffalo, SUNY, United States.
出版信息
Curr Opin Physiol. 2018 Apr;2:114-122. doi: 10.1016/j.cophys.2018.02.002. Epub 2018 Feb 22.
Abstract
NMDA receptors are a diverse family of excitatory channels with critical roles in central synaptic transmission, development, and plasticity. Controlled expression of seven subunits and their combinatorial assembly into tetrameric receptors produces a range of molecularly distinct receptor subtypes. Despite relatively similar atomic structures, each subtype has input-output functions with unique biophysical and pharmacologic profiles. Here, we briefly summarize recent advances in understanding how gating and allosteric modulation are similar or distinct across NMDA receptor isoforms and identify open questions that will focus research in this area going forward.
摘要
NMDA受体是一类多样的兴奋性通道家族，在中枢突触传递、发育和可塑性方面发挥着关键作用。七个亚基的可控表达及其组合装配成四聚体受体产生了一系列分子结构不同的受体亚型。尽管原子结构相对相似，但每个亚型都具有独特的生物物理和药理学特征的输入-输出功能。在这里，我们简要总结了在理解NMDA受体亚型间门控和变构调节如何相似或不同方面的最新进展，并确定了未来该领域研究将聚焦的开放性问题。
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