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伴有持续性先兆但无梗死的偏头痛状态型大脑常染色体显性动脉病伴皮质下梗死和白质脑病（CADASIL）。

CADASIL presenting as status migrainosus and persisting aura without infarction.

作者信息

Sacco Simona, Rasura Maurizia, Cao Marina, Bozzao Alessandro, Carolei Antonio

机构信息

Department of Neurology, The Regional Headache Referral Center, University of L'Aquila, L'Aquila, Italy.

出版信息

J Headache Pain. 2009 Feb;10(1):51-3. doi: 10.1007/s10194-008-0079-x. Epub 2008 Oct 25.

DOI:10.1007/s10194-008-0079-x
PMID:18953486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3451763/
Abstract

Different types of migraine have been reported in 20-40% of patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). We describe a novel migrainous manifestation of CADASIL consisting in status migrainosus and persistent aura without infarction. The symptoms resolved after i.v. treatment with lorazepam and mannitol.

摘要

在20%-40%的伴有皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病（CADASIL）患者中报告了不同类型的偏头痛。我们描述了一种CADASIL新的偏头痛表现，即偏头痛持续状态和无梗死的持续性先兆。症状在静脉注射劳拉西泮和甘露醇治疗后缓解。

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CADASIL presenting as status migrainosus and persisting aura without infarction.伴有持续性先兆但无梗死的偏头痛状态型大脑常染色体显性动脉病伴皮质下梗死和白质脑病（CADASIL）。
J Headache Pain. 2009 Feb;10(1):51-3. doi: 10.1007/s10194-008-0079-x. Epub 2008 Oct 25.
2
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PLoS One. 2016 Jun 16;11(6):e0157613. doi: 10.1371/journal.pone.0157613. eCollection 2016.
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Grey matter volume alterations in CADASIL: a voxel-based morphometry study.

本文引用的文献

1
Non-convulsive status epilepticus causing focal neurological deficits in CADASIL.伴有皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病（CADASIL）中导致局灶性神经功能缺损的非惊厥性癫痫持续状态
J Neurol Neurosurg Psychiatry. 2007 Nov;78(11):1287-9. doi: 10.1136/jnnp.2007.124800.
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Migraine attributed to genetic disorder.归因于遗传疾病的偏头痛。
Funct Neurol. 2007 Apr-Jun;22(2):117-8.
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Comorbid neuropathologies in migraine.偏头痛中的共病神经病理学。
J Headache Pain. 2012 Apr;13(3):231-8. doi: 10.1007/s10194-012-0418-9. Epub 2012 Feb 3.
4
Rapid improvement of a complex migrainous episode with sodium valproate in a patient with CADASIL.卡迪纳尔-斯旺综合征患者丙戊酸钠治疗复杂偏头痛发作迅速改善。
J Headache Pain. 2012 Jan;13(1):95-7. doi: 10.1007/s10194-011-0400-y. Epub 2011 Nov 8.
5
Diagnostic criteria for CADASIL in the International Classification of Headache Disorders (ICHD-II): are they appropriate?CADASIL 的国际头痛疾病分类（ICHD-II）诊断标准：是否恰当？
J Headache Pain. 2010 Jun;11(3):181-6. doi: 10.1007/s10194-010-0203-6. Epub 2010 Mar 12.
J Headache Pain. 2006 Sep;7(4):222-30. doi: 10.1007/s10194-006-0300-8. Epub 2006 Jun 15.
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Migraine with aura and brain magnetic resonance imaging abnormalities in patients with CADASIL.伴有偏头痛先兆和脑磁共振成像异常的伴有皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病患者
Arch Neurol. 2004 Aug;61(8):1237-40. doi: 10.1001/archneur.61.8.1237.
5
The International Classification of Headache Disorders: 2nd edition.《国际头痛疾病分类：第二版》
Cephalalgia. 2004;24 Suppl 1:9-160. doi: 10.1111/j.1468-2982.2003.00824.x.
6
"CADASIL coma": an underdiagnosed acute encephalopathy.“伴有皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病昏迷”：一种诊断不足的急性脑病
J Neurol Neurosurg Psychiatry. 2003 Feb;74(2):249-52. doi: 10.1136/jnnp.74.2.249.
7
Cerebral hemodynamics in CADASIL before and after acetazolamide challenge assessed with MRI bolus tracking.使用MRI团注追踪评估乙酰唑胺激发前后CADASIL患者的脑血流动力学。
Stroke. 2000 Aug;31(8):1904-12. doi: 10.1161/01.str.31.8.1904.
8
The natural history of CADASIL: a pooled analysis of previously published cases.大脑常染色体显性动脉病伴皮质下梗死和白质脑病（CADASIL）的自然病史：对既往发表病例的汇总分析
Stroke. 1999 Jun;30(6):1230-3. doi: 10.1161/01.str.30.6.1230.
9
The phenotypic spectrum of CADASIL: clinical findings in 102 cases.伴有皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病（CADASIL）的表型谱：102例临床发现
Ann Neurol. 1998 Nov;44(5):731-9. doi: 10.1002/ana.410440506.
10
Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia.伴有皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病（CADASIL）中的Notch3突变，这是一种导致中风和痴呆的遗传性成人发病疾病。
Nature. 1996 Oct 24;383(6602):707-10. doi: 10.1038/383707a0.