Kessabi Kaouthar, Kerkeni Abdelhamid, Saïd Khaled, Messaoudi Imed
UR 09/30: Génétique, Biodiversité et Valorisation des Bioressources, Institut de Biotechnologie, Université de Monastir, Monastir, Tunisia.
Biol Trace Elem Res. 2009 Apr;128(1):72-81. doi: 10.1007/s12011-008-8255-z. Epub 2008 Oct 25.
The aim of this study was to investigate the possible influence of environmental exposure to cadmium (Cd) on the spinal deformities occurrence in the Mediterranean killifish, Aphanius fasciatus (Pisces: Cyprinodontidae). For this purpose, some indicators of skeletal bone mineralization, Cd, and calcium (Ca) concentrations in spinal column as well as bioaccumulation of Cd from the water and the sediment have been compared in normal and deformed fish collected from polluted (S1) and nonpolluted (S2) areas in the Gulf of Gabès in Tunisia. When compared to the normal fish, the deformed fish showed signs of spinal column demineralization such as significant decrease in the ash weight/dry weight ratio, percentage of nonorganic components content, and Ca concentration. Cd concentrations in spinal column and liver were significantly higher in deformed fish than in normal fish. A highly significant negative correlation (r = -0.915, p < 0.01) between Cd and Ca concentrations was noted in spinal column of deformed fish. Bioaccumulation factors of Cd in the liver from the water and the sediment in deformed fish were also significantly higher (p < 0.0001) than in normal fish from S1 and S2. These findings suggest that the ability to accumulate large amount of Cd may represent a potential risk to induce spinal deformities in natural populations of Mediterranean killifish.
本研究的目的是调查环境镉（Cd）暴露对地中海鳉鱼（Aphanius fasciatus，硬骨鱼纲：鲤齿科）脊柱畸形发生的可能影响。为此，比较了从突尼斯加贝斯湾污染区（S1）和未污染区（S2）采集的正常和畸形鱼类脊柱中骨骼矿化、Cd和钙（Ca）浓度的一些指标，以及水中和沉积物中Cd的生物累积情况。与正常鱼相比，畸形鱼表现出脊柱脱矿质的迹象，如灰重/干重比、无机成分含量百分比和Ca浓度显著降低。畸形鱼脊柱和肝脏中的Cd浓度显著高于正常鱼。在畸形鱼的脊柱中，Cd和Ca浓度之间存在极显著的负相关（r = -0.915，p < 0.01）。畸形鱼肝脏中来自水和沉积物的Cd生物累积因子也显著高于S1和S2区的正常鱼（p < 0.0001）。这些发现表明，大量累积Cd的能力可能是导致地中海鳉鱼自然种群脊柱畸形的潜在风险。
