Ward Nicholas S, Casserly Brian, Ayala Alfred
Division of Pulmonary, Critical Care, and Sleep Medicine, The Warren Alpert Medical School of Brown University, 593 Eddy Street, APC 707, Providence, RI 02912, USA.
Clin Chest Med. 2008 Dec;29(4):617-25, viii. doi: 10.1016/j.ccm.2008.06.010.
Like the systemic inflammatory response syndrome (SIRS), the compensatory anti-inflammatory response syndrome (CARS) is a complex pattern of immunologic responses to severe infection or injury. The difference is that while SIRS is a proinflammatory response tasked with killing infectious organisms through activation of the immune system, CARS is a global deactivation of the immune system tasked with restoring homeostasis. Much research now suggests that the timing and relative magnitude of this response have a profound impact on patient outcomes.
与全身炎症反应综合征（SIRS）一样，代偿性抗炎反应综合征（CARS）是对严重感染或损伤的一种复杂免疫反应模式。不同的是，SIRS是一种促炎反应，其任务是通过激活免疫系统来杀灭感染性生物体，而CARS是免疫系统的全面失活，其任务是恢复体内平衡。现在许多研究表明，这种反应的时机和相对强度对患者的预后有深远影响。
